{"created":"2023-06-19T11:39:54.042437+00:00","id":8123,"links":{},"metadata":{"_buckets":{"deposit":"b37c4f4e-4929-4490-bd76-e396d513027b"},"_deposit":{"created_by":15,"id":"8123","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8123"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008123","sets":["631:636:1692684589395"]},"author_link":["20156","20151","20152","20153"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-06-01","bibliographicIssueDateType":"Issued"}}]},"item_8_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"20156","nameIdentifierScheme":"WEKO"}]}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Toll-like receptor 4(TLR4)を介した細胞内シグナル伝達においてMyD88依存経路が肺虚血再灌流障害を、MyD88非依存経路がischemic preconditioningを誘導することが示された。したがって、TLR4からNF-κBに至るシグナル伝達経路の相違がNF-κBの相反する作用の振り分けに関与していることが示唆された。Ischemic preconditioning is mediated a MyD88-independent pathway, leading to NF-κB activation and protection against lung ischemia reperfusion injury. We conclude that an activation of MyD88 or TRIF, which are associate proteins of Toll-like receptor 4, would regulate a role of NF-κB to injure or preserve lung function.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成21~23年度科学研究費補助金(基盤研究（C）)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21591811","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Toll-like receptor 4 mediates lung ischemia-reperfusion injury"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島本, 亮","creatorNameLang":"ja"},{"creatorName":"SHIMAMOTO, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高尾, 仁二","creatorNameLang":"ja"},{"creatorName":"TAKAO, Motoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"庄村, 心","creatorNameLang":"ja"},{"creatorName":"SHOMURA, Shin","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K16830.pdf","filesize":[{"value":"571.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K16830.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8123/files/39K16830.pdf"},"version_id":"1f1579de-cffe-46c0-ab5b-2f31e04f9855"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"外科","subitem_subject_scheme":"Other"},{"subitem_subject":"移植・再生医療","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肺虚血再灌流障害の発症機序 : ＴＬＲ４を介した細胞内シグナル伝達経路の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺虚血再灌流障害の発症機序 : ＴＬＲ４を介した細胞内シグナル伝達経路の解明","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684589395"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"8123","relation_version_is_last":true,"title":["肺虚血再灌流障害の発症機序 : ＴＬＲ４を介した細胞内シグナル伝達経路の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-13T00:40:23.234259+00:00"}