{"created":"2023-06-19T11:39:54.254448+00:00","id":8128,"links":{},"metadata":{"_buckets":{"deposit":"eab683b1-a939-47ec-9f68-9f7827d57443"},"_deposit":{"created_by":15,"id":"8128","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8128"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008128","sets":["631:636:1692684534076"]},"author_link":["20167","20168","20169"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-15","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"線維化や組織修復のリモデリング過程において、線維芽細胞はその中心的役割を担う。今回Epithelial mesenchymal transition (EMT)の線維化に関する関与と制御方法を検討した。A549 細胞を用い、TGF-βによる刺激によってEMT 変化に関しての研究を実施。in vitro において、IL-1β、TNF-αとTGF-βの共刺激によってよりEMT が起こりやすいことを確認した。さらにブレオマイシン肺線維症モデルにおいて線維化に関与するsiRNA の投与によってin vivoにおいても線維化を抑制することを確認した。","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成19~20年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19590893","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Epithelial mesenchymal transition during airway remodeling"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 哲","creatorNameLang":"ja"},{"creatorName":"KOBAYASHI, Tetsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田口, 修","creatorNameLang":"ja"},{"creatorName":"TAGUCHI, Osamu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Esteban, Gabazza","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K16609.pdf","filesize":[{"value":"171.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K16609.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8128/files/39K16609.pdf"},"version_id":"dccc52ed-74a4-4a60-8b0f-41c63f19c01c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TGF-β","subitem_subject_scheme":"Other"},{"subitem_subject":"EMT","subitem_subject_scheme":"Other"},{"subitem_subject":"siRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"肺線維症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"上皮間葉移行の気道リモデリングへの関与とその制御方法に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"上皮間葉移行の気道リモデリングへの関与とその制御方法に関する検討","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684534076"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"8128","relation_version_is_last":true,"title":["上皮間葉移行の気道リモデリングへの関与とその制御方法に関する検討"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-10T02:31:55.441915+00:00"}