{"created":"2023-06-19T11:39:54.466558+00:00","id":8133,"links":{},"metadata":{"_buckets":{"deposit":"35ff0d01-557e-4198-b5dc-22ad5da2e980"},"_deposit":{"created_by":15,"id":"8133","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8133"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008133","sets":["631:636:1692684552772"]},"author_link":["20185"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-04-05","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"嗅神経切断後に篩板を自家筋膜片に置換すると、再生嗅神経が移植筋膜片を貫通して再生しているのを確認した。嗅神経の再生は篩板周囲の局所傷害の程度に依存し、傷害が軽度だと炎症も軽度で神経再生が良好となり、傷害が高度であると局所炎症も高度で神経再生が不良となることがわかった。ステロイド薬による消炎治療を同時に行うと、高度傷害群でも炎症が軽度となり神経再生も良好となった。","subitem_description_type":"Abstract"},{"subitem_description":"The present study wad designed to investigate if replacing the cribriform plate with fascia can facilitate olfactory nerve recovery after olfactory nerve transection. Areas of injury-associated tissue were significantly smaller in the mild injury model, and at 42 days the regenerated nerves had reestablished connections to the glomerular layer of the bulb. With severe injury, there were larger areas of injury-associated tissue, more astrocytes and macrophages, and a decrease in regenerated nerve fibers. When dexamethasone (DXM) was injected after severe injury, there was a significant reduction in injury-associated tissue, better nerve recovery and fewer astrocytes and macrophages. These results demonstrate that recovery in the olfactory system varies with the severity of injury, and that DXM treatment may have therapeutic value by reducing injury-associated tissue and improving recovery outcome.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成19~21年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19791204","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Basic science research for regenerative treatment of olfactory dysfunction by head injury"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 正佳","creatorNameLang":"ja"},{"creatorName":"KOBAYASHI, Masayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K16657.pdf","filesize":[{"value":"484.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K16657.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8133/files/39K16657.pdf"},"version_id":"9626399d-e066-450f-aa21-cbf4379ec324"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"嗅覚","subitem_subject_scheme":"Other"},{"subitem_subject":"再生","subitem_subject_scheme":"Other"},{"subitem_subject":"外傷","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"神経","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"外傷性嗅覚障害に対する嗅覚再生治療のための基礎研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"外傷性嗅覚障害に対する嗅覚再生治療のための基礎研究","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684552772"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"8133","relation_version_is_last":true,"title":["外傷性嗅覚障害に対する嗅覚再生治療のための基礎研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-10T02:41:29.655656+00:00"}