{"created":"2023-06-19T11:39:54.508717+00:00","id":8134,"links":{},"metadata":{"_buckets":{"deposit":"32b9f8aa-9d1d-449f-bb12-c6a0e007b3b8"},"_deposit":{"created_by":15,"id":"8134","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8134"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008134","sets":["631:636:1692684589395"]},"author_link":["20187","20188"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-04-13","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は、CDDP-NAC(N-アセチルシステイン複合体)の尿細管輸送に関わる薬物トランスポータの役割を解明することを目的として実施した。OCT2, OAT1, OAT3を発現させたHEK細胞では、CDDP-NACの細胞内取り込み速度はCDDP単独に比べ低下していたことから、NAC投与はCDDPの尿細管への取り込みを低下させることで、腎毒性を軽減する可能性がある。","subitem_description_type":"Abstract"},{"subitem_description":"This study was performed to investigate the characteristics of renal tubular transport of N-acetylcysteine conjugate of cisplatin(CDDP-NAC, cytotoxic metabolite). In the human embryonic kidney 293(HEK293) cells transfected OCT2, OAT1 or OAT3, the CDDP-NAC accumulation in these cells was significantly lower than that of CDDP alone. NAC treatment prevented CDDP uptake in renal tubular cells, which might contribute to the reduced toxicity of CDDP.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成22~23年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"22790153","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Basic research for the prevention of cisplatin-induced renal toxicity based on the characteristics of renal tubular transport of its cytotoxic metabolite"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩本, 卓也","creatorNameLang":"ja"},{"creatorName":"IWAMOTO, Takuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"奥田, 真弘","creatorNameLang":"ja"},{"creatorName":"OKUDA, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K16872.pdf","filesize":[{"value":"438.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K16872.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8134/files/39K16872.pdf"},"version_id":"b5e02736-abbd-4716-b7a1-28767737afd0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"シスプラチン","subitem_subject_scheme":"Other"},{"subitem_subject":"腎障害","subitem_subject_scheme":"Other"},{"subitem_subject":"薬物トランスポータ","subitem_subject_scheme":"Other"},{"subitem_subject":"システイン複合体","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"シスプラチン毒性代謝物の尿細管輸送特性に基づく腎障害予防法の基盤構築","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"シスプラチン毒性代謝物の尿細管輸送特性に基づく腎障害予防法の基盤構築","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684589395"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"8134","relation_version_is_last":true,"title":["シスプラチン毒性代謝物の尿細管輸送特性に基づく腎障害予防法の基盤構築"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-13T00:40:27.888011+00:00"}