{"created":"2023-06-19T11:39:54.635718+00:00","id":8137,"links":{},"metadata":{"_buckets":{"deposit":"bdc7d0d4-f5cc-4414-ad63-3b6715449278"},"_deposit":{"created_by":15,"id":"8137","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8137"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008137","sets":["631:636:1692684589395"]},"author_link":["20199"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-31","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脂肪肝モデルラットを用いて、部分肝移植を行い、抗血栓作用の他に、抗炎症作用、抗アポトーシス作用のあるAPCやTMを投与して脂肪肝過小グラフトの生着向上が証明されつつある。また、細胞レベルでの、固有の生物活性（抗血栓、抗炎症、アポトーシス制御、血管新生制御作用など）の探索では、APCとTMの有用性が明らかとなりつつある。肝移植モデルのほかに、肝移植に近い肝大量切除後の虚血再還流モデルを作成し、移植モデルと同様な微小循環障害のメカニズムの解明に努めている。現段階ではAPC投与群では生存率は向上し、肝類同内皮障害の軽減と肝細胞実質障害の軽減を認めるところまでは突き止めている。","subitem_description_type":"Abstract"},{"subitem_description":"The problems associated with small-for-size liver grafts (ie, high mortality rates, postoperative complications, and acute rejection) remain critical issues in partial orthotopic liver transplantation (OLT). In association with partial OLT, splenectomy (SP) is a procedure used to reduce the portal pressure. However, the precise effects of SP on partial OLT have been unclear. In this study, using small-for-size liver grafts in rats, we examined the cytoprotective effects of SP on OLT. Liver grafts were assigned to 2 groups: a control group (OLT alone) and an SP group (OLT after SP). SP significantly increased animal survival and decreased liver damage. SP exerted the following cytoprotective effects: (1) it improved hepatic microcirculation and prevented increases in the portal pressure after OLT, (2) it suppressed the hepatic infiltration of neutrophils and macrophages through the direct elimination of splenic inflammatory cells before OLT, (3) it decreased the hepatic expression of tumor necrosis factor a and interleukin-6, (4) it attenuated sinusoidal endothelial injury, (5) it decreased plasma endothelin 1 levels and increased hepatic heme oxygenase 1 expression, (6) it suppressed hepatocellular apoptosis through the down-regulation of hepatic caspase-3 and caspase-8 activity, and (7) it increased hepatic regeneration. In conclusion, SP for small-for-size grafts exerts dual cytoprotective effects by preventing excessive portal vein hepatic inflow and eliminating splenic inflammatory cell recruitment into the liver; this in turn inhibits hepatocellular apoptosis and improves liver regeneration.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2009年度～2012年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21791279","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Study of using small-for-size fatty liver graft for liver transplantation"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"水野, 修吾","creatorNameLang":"ja"},{"creatorName":"MIZUNO, SHUGO","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K17190.pdf","filesize":[{"value":"416.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K17190.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8137/files/39K17190.pdf"},"version_id":"1b6729b3-f985-49c6-a33e-02fdc722678b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝移植","subitem_subject_scheme":"Other"},{"subitem_subject":"脂肪肝","subitem_subject_scheme":"Other"},{"subitem_subject":"過小グラフト","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝移植医療における脂肪肝過小グラフトの限界と挑戦","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝移植医療における脂肪肝過小グラフトの限界と挑戦","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684589395"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-18"},"publish_date":"2014-12-18","publish_status":"0","recid":"8137","relation_version_is_last":true,"title":["肝移植医療における脂肪肝過小グラフトの限界と挑戦"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-13T00:40:32.397750+00:00"}