{"created":"2023-06-19T11:39:54.807995+00:00","id":8141,"links":{},"metadata":{"_buckets":{"deposit":"e4676402-0dd0-4e28-9d49-7b35cf658e3e"},"_deposit":{"created_by":15,"id":"8141","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8141"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008141","sets":["631:636:1692684609508"]},"author_link":["20217"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-30","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"上皮間葉移行に関わるMicroRNA-200cはエピジェネティックな制御により原発部位に比べ有意に癌転移部位で高発現であることを証明した。またこの実験結果をもとに、癌転移部位（リンパ節転移、肝転移）から分泌されるmicroRNA-200cを血清で測定することで、大腸癌術後再発ならびに予後不良な患者を選択できることを証明した。","subitem_description_type":"Abstract"},{"subitem_description":"We showed that EMT-MET switch are regulated by promoter methylation status of CpG island of miR-200c family and expression of miR-200c in metastatic sites is significantly higher than that in primary sites. In addition, we demonstrated that serum miR-200c has a strong potential to serve as a noninvasive biomarker for CRC prognosis and predicting metastasis.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2011年度～2012年度科学研究費補助金(研究活動スタート支援)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"23890083","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Molecular mechanism of epigenetic alteration associated with lung metastasis formation in colorectal cancer and therapeutic application based on the mechanism."}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤川, 裕之","creatorNameLang":"ja"},{"creatorName":"FUJIKAWA, HIROYUKI","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K17186.pdf","filesize":[{"value":"298.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K17186.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8141/files/39K17186.pdf"},"version_id":"2ec807ef-c0ee-4007-876f-d58f76025959"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"遠隔転移","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"epigenetic","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大腸癌肺転移形成に関与するエピジェネティック変化の分子機構と治療への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸癌肺転移形成に関与するエピジェネティック変化の分子機構と治療への応用","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684609508"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-18"},"publish_date":"2014-12-18","publish_status":"0","recid":"8141","relation_version_is_last":true,"title":["大腸癌肺転移形成に関与するエピジェネティック変化の分子機構と治療への応用"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-13T00:54:08.195884+00:00"}