{"created":"2023-06-19T11:39:54.851626+00:00","id":8142,"links":{},"metadata":{"_buckets":{"deposit":"186c9bb2-bcf0-4d5c-9bc1-0796391dfb4d"},"_deposit":{"created_by":15,"id":"8142","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8142"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008142","sets":["631:636:1692684609508"]},"author_link":["20219","20220","20221","20222"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-12","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"軟骨損傷に対する新しい治療法としてテネイシンC（TNC）に着目した。ヒト関節軟骨を培養し、TNCを添加したところ軟骨細胞増殖作用、プロテオグリカン合成促進作用を認めた。TNCの関節軟骨欠損に対する治療効果を調べるために、マウスの膝関節に軟骨全層欠損を作り、TNCを局所投与した。TNCを投与すると、プロテオグリカンやII型コラーゲンの豊富な軟骨修復が得られ、軟骨修復促進剤として有用である可能性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"We used tenascin-C (TNC) to enhance cartilage repair. The treatment of human articular chondrocytes with TNC accelerated chondrocyte proliferation and stimulation of proteoglycan synthesis. Cartilage defects were created in the murine knee. Proteoglycan and type II collagen rich cartilage was regenerated after administration of TNC. Local administration of TNC could promote the cartilage repair.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2010年度～2012年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"22591684","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Molecular mechanism of cartilage repair using tenascin C and application for treatment"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長谷川, 正裕","creatorNameLang":"ja"},{"creatorName":"HASEGAWA, MASAHIRO","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"湏藤, 啓広","creatorNameLang":"ja"},{"creatorName":"SUDO, AKIHIRO","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"辻井, 雅也","creatorNameLang":"ja"},{"creatorName":"TUJII, MASAYA","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉田, 利通","creatorNameLang":"ja"},{"creatorName":"YOSHIDA, TOSHIMICHI","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K17173.pdf","filesize":[{"value":"359.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K17173.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8142/files/39K17173.pdf"},"version_id":"70924f48-1b41-4cff-bf9b-9dfbca8faebc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨","subitem_subject_scheme":"Other"},{"subitem_subject":"軟骨代謝学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"テネイシンＣの軟骨修復促進作用における分子機構の解明とその治療への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"テネイシンＣの軟骨修復促進作用における分子機構の解明とその治療への応用","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684609508"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-18"},"publish_date":"2014-12-18","publish_status":"0","recid":"8142","relation_version_is_last":true,"title":["テネイシンＣの軟骨修復促進作用における分子機構の解明とその治療への応用"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-13T00:54:12.356417+00:00"}