{"created":"2023-06-19T11:39:54.978843+00:00","id":8145,"links":{},"metadata":{"_buckets":{"deposit":"124b6cd5-51d3-4f07-97ef-42c87efb0cd1"},"_deposit":{"created_by":15,"id":"8145","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8145"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008145","sets":["631:636:1692684589395"]},"author_link":["20237"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-03-06","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"消化器癌転移メカニズムの解明と克服法の確立は生命予後改善に大きく貢献する。そこで本研究では、癌転移、とりわけ胃癌腹膜播種転移の分子シグナル機構の解明を目的として胃癌同時性腹膜播種を認めたhuman clinical sampleを中心としたmiRNA解析とcDNA発現解析を行った。胃癌組織におけるmiR-151-5p発現が腹膜播種群と有意な相関を示し、独立予後規定因子を示した。 In vitroでは、miR-151-5p発現抑制が増殖能、浸潤能を有意に抑制していることが確認された。現在、さらなる機能解析を行っている。","subitem_description_type":"Abstract"},{"subitem_description":"Establishment of metastasis mechanism contributes greatly to improving prognosis. The aim of this study is to clarify the significance of miRNA / mRNA expression profile in gastric cancer tissues and to clarify the mechanism of peritoneal metastasis in gastric cancer. MiR151-5p expression analysis in cancer tissue and adjascent normal mucosa in gastric cancer patientsdemonstrated that overexpression of miR151-5p was significantly correlated with synchronous peritoneal metastasis and poor prognosis in gastric cancer patients. In vitro analysis,downregulation of miR151-5p suppressed the proliferation and invasive ability in gastric cancer cells. On the other hand, we have demonstrated that brain derived neurotrophic factor / tropomyosin-related kinase B pathway is deeply involved in the formation of peritonealmetastasis in the gastric cancer.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2011度～2012年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"23791525","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"MicroRNA expression analysis of the gastric cancer peritoneal carcinomatosis"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"奥川, 喜永","creatorNameLang":"ja"},{"creatorName":"OKUGAWA, YOSHINAGA","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K17224.pdf","filesize":[{"value":"552.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K17224.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8145/files/39K17224.pdf"},"version_id":"87c1f34f-27ed-4359-a53d-230c40f624da"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胃十二指腸外科学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マイクロＲＮＡ網羅的解析を用いた胃癌腹膜播種転移の分子機構解明と新規治療法開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マイクロＲＮＡ網羅的解析を用いた胃癌腹膜播種転移の分子機構解明と新規治療法開発","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684589395"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-18"},"publish_date":"2014-12-18","publish_status":"0","recid":"8145","relation_version_is_last":true,"title":["マイクロＲＮＡ網羅的解析を用いた胃癌腹膜播種転移の分子機構解明と新規治療法開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-13T00:40:36.904550+00:00"}