{"created":"2023-06-19T11:39:55.021496+00:00","id":8146,"links":{},"metadata":{"_buckets":{"deposit":"8ae11d8f-9474-492c-bf16-dc4a1a32022a"},"_deposit":{"created_by":15,"id":"8146","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8146"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008146","sets":["631:636:1692684649876"]},"author_link":["20239"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-23","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"microRNA-145 (miR-145)が、小腸のP-糖タンパク質(P-gp)の発現・機能を制御することを明らかにした。この成果は、miRNAによる小腸P-gpの転写後発現調節を示す世界初の報告である。さらに、miRNAは小腸上皮細胞に発現する薬物動態制御タンパク質の発現・機能を制御することから、薬物体内動態及び薬物吸収動態の個体内・個体間変動の要因となる可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"We found that microRNA-145 (miR-145) regulates the expression and function of P-glycoprotein (P-gp) in the small intestine. This result provide new insight into the post-transcriptional regulation of intestinal P-gp. Moreover, miRNAs regulate the expression and function of proteins regulating pharmacokinetics in intestinal epithelial cells. Therefore, miRNAs could be significant factors affecting inter- and intra-individual variations in the pharmacokinetics and intestinal absorption of drugs.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2011年度～2013年度科学研究費補助金(若手研究（B）)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"23790206","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Role of oxidative stress-responsive miRNA on the variation of expression and function of protein regulating pharmacokinetics"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池村, 健治","creatorNameLang":"ja"},{"creatorName":"IKEMURA, Kenji","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K17549.pdf","filesize":[{"value":"895.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K17549.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8146/files/39K17549.pdf"},"version_id":"e96eca96-272b-460c-b61d-43507af88463"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"マイクロRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"P-糖タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"薬物体内動態","subitem_subject_scheme":"Other"},{"subitem_subject":"小腸上皮細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"転写後調節","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"薬物動態制御タンパク質の発現・機能変動おける酸化ストレス応答性miRNAの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬物動態制御タンパク質の発現・機能変動おける酸化ストレス応答性miRNAの役割","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684649876"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-01-15"},"publish_date":"2016-01-15","publish_status":"0","recid":"8146","relation_version_is_last":true,"title":["薬物動態制御タンパク質の発現・機能変動おける酸化ストレス応答性miRNAの役割"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-13T01:07:01.012904+00:00"}