{"created":"2023-06-19T11:39:55.064456+00:00","id":8147,"links":{},"metadata":{"_buckets":{"deposit":"a7cd08ab-7468-40aa-9c58-ec83cdd7937b"},"_deposit":{"created_by":15,"id":"8147","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8147"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008147","sets":["631:636:1692684649876"]},"author_link":["20241"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-17","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"(1) 肝左葉グラフトを想定したラット肝虚血再還流実験モデルにて、組み換えヒト可溶性トロンボモジュリン(rhsTM)の肝保護効果について検討した。rhsTM群にて、肝障害を示す血中肝酵素、肝組織にて炎症細胞浸潤を示すED-1免疫染色、アポトーシスを示すTUNEL染色、肝再生率を示すPCNA免疫染色にて対照群と比較して効果を認めた。(2) ヒト生体肝移植例における凝固・抗凝固因子が周術期での変化と予後を検討した。脾臓摘出の有無にかかわらず、手術後の血小板低値（10万以下）が継続は予後不良因子であった。類洞内皮細胞障害によるADAMTS13の減少と肝細胞傷害による低TPOの関与もした。","subitem_description_type":"Abstract"},{"subitem_description":"1) In the rat liver ischemia reperfusion model, the hepatic protection effect of recombination human soluble thrombomodulin (rhsTM) was examined. In the rhsTM group, liver enzymeserum, ED-1, TUNEL , and PCNA immunostaining reveal effect of rhsTM administration. 2) We examined coagulation and anti-anticoagulation factor in living donor liver transplantation patient. The blood platelet low value (100,000 or less) of continuation was a prognostic factor after liver transplantation. To determine risk factors associated with prolonged thrombocytopenia following LDLT, with a focus on the activity of ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs member 13) and the influence of splenectomy. Prolonged thrombocytopenia after LDLT was associated with not only a decrease in ADAMTS13 due to sinusoidal endothelial cell injury, but also low TPO production due to hepatocyte dysfunction, irrespective of history of splenectomy.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2010年度～2013年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"22791247","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"The challenge to the liver transplantation by a fatty liver. : Treatment strategy for inflammation and coagulation by ischemia reperfusion injury."}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岸和田, 昌之","creatorNameLang":"ja"},{"creatorName":"KISHIWADA, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20241","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K17506.pdf","filesize":[{"value":"147.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K17506.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8147/files/39K17506.pdf"},"version_id":"1f24d162-dabb-4e95-b2b2-4dd86af3cc7d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"凝固・抗凝固因子","subitem_subject_scheme":"Other"},{"subitem_subject":"肝虚血再環流障害","subitem_subject_scheme":"Other"},{"subitem_subject":"生体肝移植","subitem_subject_scheme":"Other"},{"subitem_subject":"マージナルドナー","subitem_subject_scheme":"Other"},{"subitem_subject":"ADAMS13","subitem_subject_scheme":"Other"},{"subitem_subject":"TPO","subitem_subject_scheme":"Other"},{"subitem_subject":"血小板","subitem_subject_scheme":"Other"},{"subitem_subject":"可溶性トロンボモジュリン(rhsTM)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脂肪肝による肝移植への挑戦 : 虚血再還流障害から移植を炎症と凝固を礎として","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脂肪肝による肝移植への挑戦 : 虚血再還流障害から移植を炎症と凝固を礎として","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684649876"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-01-15"},"publish_date":"2016-01-15","publish_status":"0","recid":"8147","relation_version_is_last":true,"title":["脂肪肝による肝移植への挑戦 : 虚血再還流障害から移植を炎症と凝固を礎として"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-13T01:07:01.212361+00:00"}