{"created":"2023-06-19T11:39:55.323596+00:00","id":8153,"links":{},"metadata":{"_buckets":{"deposit":"2240c80a-1c22-461d-8c06-ae4a76f76439"},"_deposit":{"created_by":15,"id":"8153","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8153"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008153","sets":["631:636:1692684649876"]},"author_link":["20273","20274"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-26","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"リポポリ多糖類（LPS）投与により作製した炎症モデルラットにメトトレキサート（MTX）を静脈内投与したところ、LPSラットではMTXの血漿クリアランス（CL）が対照に比べ約50%まで低下した。LPS処置によるMTXの腎CL低下には、糸球体ろ過速度に加え尿細管分泌低下の関与が示唆された。MTXの腎組織／血漿中濃度比、腎組織から管腔への排泄CLはLPSラットで低下し、有機アニオントランスポータ群（rOAT1、rOAT3、rMRP2、rMRP4）の発現量低下と対応していた。結果、LPS処置ラットではMTXの腎CLが顕著に低下し、糸球体ろ過低下と有機アニオントランスポータの発現低下の寄与が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Plasma clearance of methotrexate (MTX) decreased about 50% in the inflammatory rat model, which is prepared by the administration of lipopolysaccharide (LPS). Involvement of glomerular filtration as well as tubular secretion were suggested in the decreased renal clearance of MTX by LPS. Renal tissue/plasma concentration ratio and efflux clearance from renal tissue to the tubular lumen also decreased in LPS rats, and were comparable to the decreased expression levels of organic anion transporters (rOAT1, rOAT3, rMRP2, rMRP4) in the kidney. In conclusion, the renal clearance of MTX markedly decreased in the LPS-treated rats and the contribution of decreased glomerular filtration as well as decreased expression levels of organic anion transporters in the renal tubules were suggested.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2011年度～2013年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"23590180","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Regulation of functions of drug transporters in renal tubules by inflammatory cytokines and implication of its significance"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"奥田, 真弘","creatorNameLang":"ja"},{"creatorName":"OKUDA, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岩本, 卓也","creatorNameLang":"ja"},{"creatorName":"IWAMOTO, Takuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K17524.pdf","filesize":[{"value":"286.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K17524.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8153/files/39K17524.pdf"},"version_id":"349cea64-8c92-421f-9c8b-fb1d316c7009"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"メトトレキサート","subitem_subject_scheme":"Other"},{"subitem_subject":"リポ多糖","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"有機アニオントランスポータ","subitem_subject_scheme":"Other"},{"subitem_subject":"腎クリアランス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"炎症性サイトカインによる尿細管薬物トランスポータの機能制御とその役割解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症性サイトカインによる尿細管薬物トランスポータの機能制御とその役割解明","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684649876"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-01-15"},"publish_date":"2016-01-15","publish_status":"0","recid":"8153","relation_version_is_last":true,"title":["炎症性サイトカインによる尿細管薬物トランスポータの機能制御とその役割解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-13T01:07:15.145145+00:00"}