{"created":"2023-06-19T11:39:55.366818+00:00","id":8154,"links":{},"metadata":{"_buckets":{"deposit":"62e715ef-ab66-4387-8b6e-98e9c1b46dcd"},"_deposit":{"created_by":15,"id":"8154","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8154"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008154","sets":["631:636:1692684632717"]},"author_link":["20279","20280","20277","20278"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-05-19","bibliographicIssueDateType":"Issued"}}]},"item_8_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IWAMOTO, Shotaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HIRAYAMA, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20280","nameIdentifierScheme":"WEKO"}]}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"N－カドヘリンは、カルシウム依存性細胞間接着分子の一つで、細胞骨格形成に関わるとともに、正常造血において重要な役割を担っている。今回、小児急性白血病に注目し、白血病－骨髄ニッチにおける同分子の臨床的意義を検討した。N－カドヘリンはprimary/hTERT不死化骨髄由来ストローマ細胞（BMSCs)で高発現し、急性白血病の細胞株及び初発時検体のなかにも発現することを認めた。更に、BMSCsと白血病細胞との共培養実験で、同分子の接着抑制抗体を用いると、白血病細胞の薬剤感受が増強した。以上から、N－カドヘリンは、骨髄微小環境における小児急性白血病細胞の薬剤耐性機序に関与することが予想された。","subitem_description_type":"Abstract"},{"subitem_description":"N-cadherin, a family of Ca2+-dependent intercellular adhesion molecules, plays　key roles in controlling morphogenetic movements during development and hematopoiesis in bone marrow (BM). Recently, it has been reported that this molecule might be associated with drug resistance in adult leukemia. Then we studied the clinical significance of N-cadherin in BM niche in acute childhood leukemia. We found that N-cadherin was highly expressed on primary / hTERT immortalized BM stroma cells (BMSCs). Several kinds of leukemic cell lines and primary childhood leukemia cells also expressed different levels of N-cadherin. In addition, drug sensitivity in leukemic cells for anti-leukemic agents in co-culture system between leukemic cells and BMSCs increased in the presence of GC-4 antibody that can inhibit N-cadherin adherens junction formation .Taken together, these results supported that N-cadherin might be related to drug resistance in childhood acute leukemic cells in BM microenvironments.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2012年度～2014年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"24591546","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Elucidation of the N-cadherin molecular mechanism in the leukemia microenvironment in bone marrow and the central nervous system"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩本, 彰太郎","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平山, 雅浩","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K17877.pdf","filesize":[{"value":"218.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K17877.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8154/files/39K17877.pdf"},"version_id":"c3717ea2-8feb-423a-99bc-c36f6ceb9c28"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"N-カドヘリン","subitem_subject_scheme":"Other"},{"subitem_subject":"白血病微小環境","subitem_subject_scheme":"Other"},{"subitem_subject":"急性白血病","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"白血病微小環境（骨髄及び中枢神経系）におけるＮ―カドヘリン分子機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"白血病微小環境（骨髄及び中枢神経系）におけるＮ―カドヘリン分子機構の解明","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684632717"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-13"},"publish_date":"2017-01-13","publish_status":"0","recid":"8154","relation_version_is_last":true,"title":["白血病微小環境（骨髄及び中枢神経系）におけるＮ―カドヘリン分子機構の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-08-30T06:21:29.505493+00:00"}