{"created":"2023-06-19T11:39:55.594169+00:00","id":8159,"links":{},"metadata":{"_buckets":{"deposit":"d17db118-8932-4d0a-b7a9-83d5f3504dfc"},"_deposit":{"created_by":15,"id":"8159","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8159"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00008159","sets":["631:636:1692684632717"]},"author_link":["20296","20297","20298","20293","20294","20295"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06-25","bibliographicIssueDateType":"Issued"}}]},"item_8_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"YAMAMOTO, Norihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SHIRAKI, Katsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20297","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SUGIMOTO, Kazushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20298","nameIdentifierScheme":"WEKO"}]}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、メタボリック症候群の増加が本邦にとって最大の問題となってきている。その病態の解明の進歩により代謝の基本臓器である肝臓の脂肪化が疾患の誘因や進展に大変重要な役割をしていることが明らかになってきた。しかし、脂肪肝、および脂肪性肝炎(NASH)の分子生物学的な機序の解明は十分になされていない。そこで、われわれは、最新のプロテオミクス解析を用い健常人とNAFLD/NASHから肝硬変に至る時間軸にそった患者由来試料を解析し、それぞれに特異的なペプチド発現データを中心に解析し、iTRAQを用いてNASH特有のペプチドを同定した。","subitem_description_type":"Abstract"},{"subitem_description":"Recently, the increasing number of metabolic syndrome has become emerging health problem in our country. As mechanism of this disease has been evaluated, it has become obvious that hepatic steatosis plays an important role in triggering and progression of the disease. Especially, non-alcoholic steatohepatitis(NASH) is very important in the pathogenesis of the disease. But the detailed role of hepatic steatosis in metabolic syndrome remains unclear. Furthermore, it is still very difficult to distinguish simple steatosis from NASH. In this study, we analyzed the blood sample from the healthy volunteer and the NAFLD patients who developed NASH and ultimately liver cirrhosis. We detected the NASH specific molecular peptide by peptidomics using iTRAQ.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2012年度～2014年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"24590969","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Investigation for biomarker of NASH by comprehensive analysis using peptidomics"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本, 憲彦","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"20293","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白木, 克哉","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"20294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"杉本, 和史","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"20295","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-18"}],"displaytype":"detail","filename":"39K17873.pdf","filesize":[{"value":"263.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K17873.pdf","url":"https://mie-u.repo.nii.ac.jp/record/8159/files/39K17873.pdf"},"version_id":"b04603ab-b72b-46bf-bd21-144c45df49e8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NASH","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテオミクス","subitem_subject_scheme":"Other"},{"subitem_subject":"iTAQ法","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"網羅的ペプチドミクスによるＮＡＳＨの病態解析と分子標的の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"網羅的ペプチドミクスによるＮＡＳＨの病態解析と分子標的の探索","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692684632717"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-13"},"publish_date":"2017-01-13","publish_status":"0","recid":"8159","relation_version_is_last":true,"title":["網羅的ペプチドミクスによるＮＡＳＨの病態解析と分子標的の探索"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-08-30T06:21:41.942212+00:00"}