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  1. 30 大学院医学系研究科・医学部
  2. 30A 学術雑誌論文
  3. 学術雑誌論文

Effects of Chronic Alcohol Use on Mouse Myocardial Tissue

http://hdl.handle.net/10076/00018377
http://hdl.handle.net/10076/00018377
1e5edc9e-e7fd-41f1-a320-e825f29228ae
名前 / ファイル ライセンス アクション
2019JA0002.pdf 2019JA0002.pdf (3.9 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2019-10-01
タイトル
タイトル Effects of Chronic Alcohol Use on Mouse Myocardial Tissue
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 alcoholism
キーワード
言語 en
主題Scheme Other
主題 sudden death
キーワード
言語 en
主題Scheme Other
主題 cardiac hypertrophy
キーワード
言語 en
主題Scheme Other
主題 microarray
キーワード
言語 en
主題Scheme Other
主題 mice
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Kozawa, Shuji

× Kozawa, Shuji

en Kozawa, Shuji

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Ikematsu, Kazuya

× Ikematsu, Kazuya

en Ikematsu, Kazuya

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Murase, Takehiko

× Murase, Takehiko

en Murase, Takehiko

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Nata, Masayuki

× Nata, Masayuki

en Nata, Masayuki

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抄録
内容記述タイプ Abstract
内容記述 Alcohol intake induces cardiovascular effects. We performed a comprehensive analysis of the gene expression profiles of myocardial tissues from a mouse model of alcohol feeding by microarray to clarify the effect of alcohol on myocardium from the perspective that the acute phase of alcohol use causes changes to myocardial injury related gene expression profiles, while the withdrawal phase is associated with changes in gene expression profiles related to myocardial protection. A model of single alcohol feeding was generated using pathogen-free, 7-weekold, male C57BL/6N mice administered a peroral injection of 7.0 g/kg ethanol (single alcohol-fed group group) or saline (control group). A repeated alcohol feeding group was generated following Lieber's method. To investigate the effects of alcohol in the alcohol-fed group, the left ventricles of hearts were extirpated 1h(alcohol group) or 24h(withdrawal group) after the last alcohol feeding. Myocardial tissues were then subjected to RNA extraction and gene expression analysis by real-time reverse transcription polymerase chain reaction. Sera were also analyzed for various signal transducers, including 22 cytokines. Using RNA extracted from extirpated myocardia, mRNA expressions were comprehensively analyzed by one-color microarray (n=4) using SurePrint G3 Mouse Gene Expression 8x60K (Agilent) containing 38,64O gene probes as the microchip, and gene ontology and gene cascade analyses were performed. Differing gene profiles were seen in the repeated alcohol intake group. In the acute phase of alcohol intake, there were changes in gene profiles related to activation of the STAT pathway and blood cytokine-mediated inflammatory responses to hypercardia. In the withdrawal from alcohol phase, changes in gene profiles related to STAT activity did not persist, although gene profile changes related to apoptosis and the development of sudden death were observed. Further detailed investigations of the effects of alcohol on cardiomyocytes are planned.
書誌情報 日本アルコール・薬物医学会雑誌
en : Japanese Journal of Alcohol Studies & Drug Dependence

巻 54, 号 1, p. 25-38, 発行日 2019-02
ISSN
収録物識別子タイプ PISSN
収録物識別子 1341-8963
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN10518421
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 一般社団法人 日本アルコール・アディクション医学会
出版者(ヨミ)
値 イッパンシャダンホウジン ニホンアルコール・アディクションイガクカイ
資源タイプ(三重大)
値 Journal Article / 学術雑誌論文
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