Ghrelin, an endogenous ligand for the growth hormone (GH) secretagogue receptor, has been reported to induce a GH-releasing, orexigenic effect on weight gain, and adipogenic actions. It is, therefore, thought that ghrelin links the regulatory systems for growth and energy balance.
We examined 25 obese children undergoing a 3-month inpatient weight reduction program for obese children based on a combination of diet and exercise therapy and evaluated the change in the serum ghrelin levels.
The subjects consisted of 25 children with moderate to severe simple obesity [17 boys, 8 girls ; mean age 9.9±1.3 years, percent overweight (% overweight) 52.1±13.6%]. Height, weight, percent body fat (% BF), fat mass, fat-free mass (FFM), and serum ghrelin were measured before and after weight reduction.
After therapy, body weight, % BF and fat mass had all significantly decreased (p<0.001), while height and FFM had both significantly increased (p<0.001 ; p<0.05, respectively). There were no correlations between pre-therapy serum ghrelin and any of the following: initial height, weight, % overweight, % BF, fat mass, or FFM. However, after therapy, serum ghrelin levels were negatively correlated with body weight (rs=-0.544, p<0.01). Serum ghrelin levels increased significantly from pre- to post-therapy (113.9±30.7 to 129.6±42.9 fmol/ml, p<0.05). The rate of changes in ghrelin levels was negatively correlated with the rate of change in the % overweight (rs=-0.412, p<0.05).
These findings suggest that long-term weight reduction based on a combination of diet and exercise therapy lessens the severity of obesity and increases serum ghrelin levels in obese children.
内容記述
肥満小児におけるメタボリックシンドロームの実態と食事、運動による改善
雑誌名
体力科學
巻
56
号
4
ページ
419 - 428
発行年
2007-01-01
ISSN
0039906X
書誌レコードID
AN00137986
権利
日本体力医学会
本文データは学協会の許諾に基づきCiNiiから複製したものである
フォーマット
application/pdf
著者版フラグ
publisher
日本十進分類法
490
その他のタイトル
Impact of a diet and exercise program for obese children on serum ghrelin levels
肥満小児に対する食事療法と運動療法を主体とした減量が血中グレリン濃度に及ぼす影響
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