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Assessment of genetic risk for myocardial infarction
http://hdl.handle.net/10076/9282
http://hdl.handle.net/10076/92822554aaff-c592-49fd-83be-84ffc238c8fc
名前 / ファイル | ライセンス | アクション |
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62A7883.pdf (404.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-11-14 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Assessment of genetic risk for myocardial infarction | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Genetics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myocardial infarction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | coronary heart disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | atherosclerosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamada, Yoshiji
× Yamada, Yoshiji× Matsuo, Hitoshi× Segawa, Tomonori× Watanabe, Sachiro× Kato, Kimihiko× Hibino, Takeshi× Yokoi, Kiyoshi× Ichihara, Sahoko× Metoki, Norifumi× Yoshida, Hidemi× Satoh, Kei× Nozawa, Yoshinori |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although lifestyle and environmental factors influence the prevalence of myocardial infarction, genetic epidemiological studies have suggested that several genetic variants increase the risk for this condition.We have performed a large-scale association study to identify gene polymorphisms for reliable assessment of the genetic risk of myocardial infarction. The study population comprised 3,483 unrelated Japanese individuals (1,913 men; 1,570 women), including 1,192 subjects with myocardial infarction and 2,291 controls.The genotypes for 164 polymorphisms of 137 candidate genes were determined with an oligonucleotide ligation assay based on analysis of fluorescent microspheres with suspension array technology. Multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of smoking, hypertension, dia-betes mellitus, and hypercholesterolemia revealed that the 677C→T (Ala222Val) polymorphism of MTHFR, the 1595C→G (Ser447Stop) polymorphism of LPL, and the –108/3G→4G polymorphism of IPF1 were significantly associated with the prevalence of myocardial infarction.A stepwise forward selection procedure demonstrated that IPF1, MTHFR, and LPL genotypes significantly affected the prevalence of myocardial infarction. Combined genotype analysis of these polymorphisms yielded a maximum odds ratio of 2.54 for the combined genotype of TT for MTHFR,CC for LPL,and 3G3G for IPF1.The genotypes for MTHFR, LPL, and IPF1 may prove reliable for assessment of genetic risk for myocardial infarction. Determination of the combined genotype for these genes may contribute to primary, personalized prevention of this condition. | |||||
書誌情報 |
Thrombosis and haemostasis : journal of the International Society on thrombosis and haemostasis 巻 96, 号 2, p. 220-227, 発行日 2006-08-01 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0340-6245 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00863137 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 16894468 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1160/TH06–02–0117 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
出版者 | ||||||
出版者 | Schattauer | |||||
関係URI | ||||||
関連名称 | http://www.schattauer.de/index.php?id=1268&pii=th06080220&no_cache=1 | |||||
ノート | ||||||
出版者版電子ジャーナルあり | ||||||
資源タイプ(三重大) | ||||||
Journal Article / 学術雑誌論文 |