| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2020-12-14 |
| タイトル |
|
|
タイトル |
The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
PD-1 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
group 2 innate lymphoid cells |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
sepsis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
acute lung injury |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
IL-13 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
IL-33 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
ST2 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
natural and inflammatory ILC2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Akama, Yuichi
Satoh-Takayama, Naoko
Kawamoto, Eiji
Ito, Atsushi
Gaowa, Arong
Park, Eun Jeong
Imai, Hiroshi
Shimaoka, Motomu
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Septic shock/severe sepsis is a deregulated host immune system response to infection that leads to life-threatening organ dysfunction. Lung inflammation as a form of acute lung injury (ALI) is often induced in septic shock. Whereas macrophages and neutrophils have been implicated as the principal immune cells regulating lung inflammation, group two innate lymphoid cells (ILC2s) have recently been identified as a new player regulating immune homeostasis. ILC2 is one of the three major ILC subsets (ILC1s, ILC2s, and ILC3s) comprised of newly identified innate immune cells. These cells are characterized by their ability to rapidly produce type 2 cytokines. ILC2s are predominant resident ILCs and, thereby, have the ability to respond to signals from damaged tissues. ILC2s regulate the immune response, and ILC2-derived type 2 cytokines may exert protective roles against sepsis-induced lung injury. This focused review not only provides readers with new insights into the signaling mechanisms by which ILC2s modulate sepsis-induced lung inflammation, but also proposes ILC2 as a novel therapeutic target for sepsis-induced ALI. |
| 書誌情報 |
Diagnostics
巻 10,
号 10,
発行日 2020-10-12
|
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2075-4418 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3390/diagnostics10100808 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
MDPI |
| 関係URI |
|
|
|
関連名称 |
https://www.mdpi.com/2075-4418/10/10/808 |
| 資源タイプ（三重大） |
|
|
値 |
Journal Article / 学術雑誌論文 |
2020JA0002 (1.4 MB)
