1. Pseudomonas anguillisepticaに感染し, 体表面に点状出血が発現した病魚について病理組織学的検討を行なった。
2. その結果, 感染病巣は真皮, 皮下脂肪組織, 体側筋組織間質, 血管壁, 心臓および動脈球に出現し, そこに漿液滲出-細胞繁殖を主徴とする炎症が起こっていた。細菌が伝播した真皮疎結合織に起こった小出血が本病に特徴的な点状出血の組織像であった。
3. 全身感染から敗血症の段階で, 肝臓にうっ血性水腫と肝細胞の脂肪変性, 脾臓に漿液滲出-組織融解-細胞増生性反応, 造血組織に萎縮と類洞細網内皮細胞の活性化が見られた。
4. 以上の所見から, 体表面に点状出血を現わした病魚は重篤な病状段階にあることがわかった。
Pseudomonas anguilliseptica infection of the Japanese eel is a new disease that was confirmed in 1971 and named red spot disease. This disease has prevailed in spring and autumn and has resulted in mass mortalities. Histopathological studies were made on 55 diseased eels that had petechial hemorrhages in the body surface and fins. Anatomically they showed congestive swelling of liver, atrophy of spleen, kidney, and pericard‐epicarditis.
Histopathological studies indicated that infected lesions appeared in dermis, subcutaneous adipose tissue, interstitial tissue of the body musculature, vascular walls, bulbus arteriosus and heart. In such lesions bacteria multiplied profusely and resulting inflammation was serous exudation and cellular infiltration‐proliferation composed of activated mesenchymal cells, wandering, large mononuclear cells, large juvenile cells and a small number of neutrophils. Many minute hemorrhages occurred in affected dermal loose connective tissue, and small hemorrhages occurred in the intraepithelial papillary tissue. In the stages of geieralized infection to the septic condition various pathological changes were observed in the visceral organs, that is, congestive edema and intensive fatty degeneration of the hepatic cells in the liver ; the reactions mixed with serous exudation, tissue liquefaction and cellular proliferation in the spleen ; infectious glomerulitis, activation of the reticulo‐endothelial cells lining sinusoids, and atrophy of the hematopoietic tissue in the kidney.
On the basis of these findings diseased eels manifested with petechial hemorrhages in the body surface are thought to be in an advanced condition of the disease.
雑誌名
魚病研究
巻
12
号
1
ページ
39 - 49
発行年
1977-06-01
ISSN
0388-788X
書誌レコードID
AN00063165
フォーマット
application/pdf
著者版フラグ
publisher
日本十進分類法
663
その他のタイトル
Histopathological Studies of Red Spot Disease of the Japanese Eel
ニホンウナギのPseudomonas anguilliseptica感染病の病理組織学的研究-I. : 自然感染
AN000631650120101.pdf
(2.77MB)
