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慢性GVHD組織線維化病態におけるテネイシン‐Cの役割の解明と標的治療法の開発
http://hdl.handle.net/10076/00018052
http://hdl.handle.net/10076/00018052b110561d-741b-4fea-8686-a6ec83745759
名前 / ファイル | ライセンス | アクション |
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2018RP0026 (90.2 kB)
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Item type | 報告書 / Research Paper(1) | |||||||||||||
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公開日 | 2019-05-08 | |||||||||||||
タイトル | ||||||||||||||
言語 | ja | |||||||||||||
タイトル | 慢性GVHD組織線維化病態におけるテネイシン‐Cの役割の解明と標的治療法の開発 | |||||||||||||
タイトル | ||||||||||||||
言語 | en | |||||||||||||
タイトル | Role of tenascin-C in development of fibrosis in chronic GVHD tissue and establishment of its targetted therapy | |||||||||||||
言語 | ||||||||||||||
言語 | jpn | |||||||||||||
キーワード | ||||||||||||||
主題Scheme | Other | |||||||||||||
主題 | GVHD | |||||||||||||
キーワード | ||||||||||||||
主題Scheme | Other | |||||||||||||
主題 | テネイシン-C | |||||||||||||
資源タイプ | ||||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||||||||||
資源タイプ | research report | |||||||||||||
著者 |
俵, 功
× 俵, 功
× 吉田, 恭子(今中 恭子)
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抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | 同種造血幹細胞移植後に起こる移植片対宿主病(GVHD)は、移植成功への障壁となる合併症の一つである。慢性GVHDは組織線維化病態を伴うのが特徴であるが、発症メカニズムは不明な点が多く、治療法も確立していない。本研究では、組織線維化を制御するテネイシン-C(TN-C)の慢性GVHD発症における役割を、マウスモデル、臨床検体を用いて検討した。マウス移植モデルでは、TN-Cを産生する細胞はレシピエント由来であることが明らかとなり、TN-Cを発現しないノックアウトマウスでは、GVHDが増悪する傾向が認められた。現在、移植患者血漿中TN-Cと慢性GVHD発症との関係を検討中である。 | |||||||||||||
抄録 | ||||||||||||||
内容記述タイプ | Abstract | |||||||||||||
内容記述 | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for refractory hematological malignancies. Complication occured after allo-HSCT such as graft-vs-host disease (GVHD) is an obstacle for successful allo-HSCT. Pathophysioligy of chronic GVHD (cGVHD) that features tissue fibrosis is still unclear and standard therpy for cGVHD has not been established yet. Tenascin-C (TN-C) is involved in tissue fibrosis and its role in cGVHD pathophysiolgy is unknown. In this study, we investigated the role of TN-C in cGVHD using mouse model and clinical samples. Mouse models demonstrated that TN-C was produced by recipient-origin cells and there was a tendency that GVHD was exacerbated in TN-C-deficient mice. Analysis of relation between TN-C level in patient's plasma and cGVHD onset is underway. | |||||||||||||
内容記述 | ||||||||||||||
内容記述タイプ | Other | |||||||||||||
内容記述 | 2014年度~2016年度科学研究費補助金(基盤研究(C))研究成果報告書 | |||||||||||||
書誌情報 |
発行日 2017-05-29 |
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フォーマット | ||||||||||||||
内容記述タイプ | Other | |||||||||||||
内容記述 | application/pdf | |||||||||||||
著者版フラグ | ||||||||||||||
出版タイプ | VoR | |||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
出版者 | ||||||||||||||
出版者 | 三重大学 | |||||||||||||
出版者(ヨミ) | ||||||||||||||
ミエダイガク | ||||||||||||||
科研費番号 | ||||||||||||||
内容記述タイプ | Other | |||||||||||||
内容記述 | 26461441 | |||||||||||||
資源タイプ(三重大) | ||||||||||||||
Kaken / 科研費報告書 |