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直腸癌術前化学放射線療法による癌間質変化と治療抵抗性・再発機序の解明
http://hdl.handle.net/10076/00019459
http://hdl.handle.net/10076/0001945961043407-75bc-4b31-8af1-c1ad06f5c421
名前 / ファイル | ライセンス | アクション |
---|---|---|
2020RP0022 (192.6 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-11-12 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 直腸癌術前化学放射線療法による癌間質変化と治療抵抗性・再発機序の解明 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Elucidation for recurrent mechanism in rectal cancer patients after CRT. | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 直腸癌 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 間質 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | バイオマーカー | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
著者 |
三枝, 晋
× 三枝, 晋× 問山, 裕二× 田中, 光司× 楠, 正人 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 直腸癌腫瘍組織中のPD-L1発現と陳勝病理学的因子との関連では直腸癌組織におけるPD-L1高発現群は、有意に脈管浸潤と相関を認め、さらに術後再発が有意に高率であった。また予後解析では、直腸癌組織中のPD-L1高発現群は、有意にrelapse free survival、ならびにoverall survivalが不良であった。さらに直腸癌周囲の間質に存在するCD8陽性リンパ球数とFoxp3陽性リンパ球数は有意に正の相関を示し、間質浸潤のCD8陽性リンパ球数は腫瘍中のPD-L1高発現群で有意に低値を示した一方、間質浸潤のFoxp3陽性リンパ球数は腫瘍中のPD-L1発現との間に関連を認めなかった。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Immunohistochemical analysis showed that elevated PD-L1 expression in rectal cancer tissues was significantly correlated with presence of lymphovascular invasion and recurrence after curative surgery. Survival curve analysis demonstrated that elevated PD-L1 expression was significantly correlated with poor overall and disease-free survival in rectal cancer patients receiving chemoradiotherapy. Furthermore, number of CD8+tumor infltrative lymphocytes (TILs) was positively correlated with FOXP3+TILs, and CD8+TILs was significantly increased in patients with high PD-L1 expression. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2016年度~2018年度科学研究費補助金(基盤研究(C))研究成果報告書 | |||||
書誌情報 |
発行日 2019-05-21 |
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フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 三重大学 | |||||
出版者(ヨミ) | ||||||
ミエダイガク | ||||||
科研費番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 16K10532 | |||||
資源タイプ(三重大) | ||||||
Kaken / 科研費報告書 |