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網羅的口腔内細菌叢の解析から検証する大腸癌発癌の機序
http://hdl.handle.net/10076/00020152
http://hdl.handle.net/10076/00020152ac599e57-1553-4c10-869e-e652628563cc
名前 / ファイル | ライセンス | アクション |
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2021RP0068 (788.9 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2022-01-24 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 網羅的口腔内細菌叢の解析から検証する大腸癌発癌の機序 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Association carcinogenesis with oral microbiota in colorectal cancer | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 大腸癌 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 潰瘍性大腸炎 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 腸内細菌 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | マイクロサテライト不安定性 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
著者 |
近藤, 哲
× 近藤, 哲× 問山, 裕二× 奥川, 喜永× 楠, 正人 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 潰瘍性大腸炎患者において直腸粘膜のDNAメチル化レベル、DMRsパネルが潰瘍性大腸炎患者関連大腸癌を高率に同定でき、有用なpredictive markerとなり得る可能性が示唆された。 大腸癌組織中のFusobacterium発現とMSI-H大腸癌との関連性が示され、MSI-H大腸癌の発癌と大腸におけるFusobacterium発現が関与する可能性が示唆された。また、口腔内細菌叢の解析には進めなかった。 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Specific miRNAs to be methylated and DMRs in rectal mucosal in patients with UC could be used to identify patients with UC at greatest risk for developing UC-CRC. Fusobacterium infection was detected in CRC tissues. Furthermore, Fusobacterium infection was significantly associated with MSI-H compared to non-MSI-H. Unfortunately, it is difficult to detect the oral microbiota and we could not process comprehensive analysis of oral microbiota. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2017年度~2019年度科学研究費補助金(基盤研究(C))研究成果報告書 | |||||
書誌情報 |
発行日 2020-05-18 |
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出版者 | ||||||
出版者 | 三重大学 | |||||
出版者(ヨミ) | ||||||
ミエダイガク | ||||||
科研費番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 17K10629 | |||||
資源タイプ(三重大) | ||||||
Kaken / 科研費報告書 |