{"_buckets": {"deposit": "b860de17-4ecf-4744-b959-231782511e48"}, "_deposit": {"created_by": 15, "id": "15270", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "15270"}, "status": "published"}, "_oai": {"id": "oai:mie-u.repo.nii.ac.jp:00015270", "sets": ["1692670514969"]}, "author_link": [], "item_8_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-06-08", "bibliographicIssueDateType": "Issued"}}]}, "item_8_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_8_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "あらたなエピゲノムとしてDNA・RNAメチル化の癌化における機序が、近年相次いで報告されてきている。今回、RNAメチル化解析は、その品質不良により安定した解析結果が得られなかったものの、DNAメチル化に関しては、DNAメチル化網羅的解析を行い、その結果から、孤発性大腸癌ならびに潰瘍性大腸炎関連大腸癌特異的に高メチル化を呈するCpGサイトを同定した。また同部位のメチル化を、非癌部直腸粘膜組織検体を用いて定量を行うことで、癌合併潰瘍性大腸炎症例を診断できる可能性を明らかにした。", "subitem_description_type": "Abstract"}, {"subitem_description": "In this study, we conducted comprehensive methylation analysis using surgical specimens from sporadic colorectal cancer or ulcerative colitis-associated CRC, and successfully identified cancer-specific hypermethylated CpG site. 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潰瘍性大腸炎関連癌におけるRNAメチル化マーカーの臨床的意義
http://hdl.handle.net/10076/00020888
http://hdl.handle.net/10076/00020888