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遊離癌細胞の生着能を利用した転移機形成序解明とあらたなHIPEC治療適応の確立
http://hdl.handle.net/10076/00020908
http://hdl.handle.net/10076/00020908ec4e7b13-6ff5-4ab4-9abd-b875f78339ba
名前 / ファイル | ライセンス | アクション |
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2022RP0051 (312.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2022-11-28 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 遊離癌細胞の生着能を利用した転移機形成序解明とあらたなHIPEC治療適応の確立 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Elucidation of the mechanism of metastasis formation using the engraftment ability of free cancer cells and establishment of new indications for HIPEC therapy | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 胃癌 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 遊離癌細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 腹膜播種 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
著者 |
安田, 裕美
× 安田, 裕美× 問山, 裕二× 奥川, 喜永× 吉山, 繫幸× 大井, 正貴× 楠, 正人 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 進行胃癌の腫瘍組織をmicroarrayで網羅的解析し、同定された候補miRNA5つのうち3miRNA(miR-30a-5p, -659-3p, -3917)はtesting cohortにおいて腹膜播種陽性症例で有意に高発現で、この3miRNAの複合パネルスコアは腹膜播種同定能でAUC:0.82であった。validationとEvaluation cohortにおいてもこの結果は再現され、多変量解析で3miRNAパネルスコアとともに抽出された内視鏡的肉眼型を組み合わせたリスクスコアの高値例は、各cohortにおいてAUC:0.87,0.76,0.79と高精度に腹膜播種陽性例を同定できた。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We performed a systematic biomarker discovery by analyzing miRNA expression profiles in primary tumors from GC patients with and without PM. Among 5 miRNA, 3 of which (miR-30a-5p, -659-3p, and -3917) were significantly overexpressed in the primary tumors from PM-positive patients in the testing cohort, and distinguished patients with the value of AUC of 0.82. The efficacy of the combination miRNA signature was subsequently validated in an independent validation cohort (AUC = 0.74). Finally, our miRNA signature when combined together with the macroscopic Borrmann's type score offered a much superior diagnostic in all 3 cohorts (AUC = 0.87,0.76, and 0.79, respectively). | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2018年度~2020年度科学研究費補助金(基盤研究(C))研究成果報告書 | |||||
書誌情報 |
発行日 2021-05-31 |
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フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 三重大学 | |||||
出版者(ヨミ) | ||||||
ミエダイガク | ||||||
科研費番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 18K08674 | |||||
資源タイプ(三重大) | ||||||
Kaken / 科研費報告書 |