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3位に置換基を有するヘキソース誘導体の好中球接着阻害作用
http://hdl.handle.net/10076/3232
http://hdl.handle.net/10076/32328478c715-51dc-4c3f-95e8-ac25488c930a
名前 / ファイル | ライセンス | アクション |
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AN100738460001605.pdf (370.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-21 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 3位に置換基を有するヘキソース誘導体の好中球接着阻害作用 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cell adhesion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 3-O-lauroyl-D-hexose derivatives | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | neutrophil | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hydrogen peroxide | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
柏村, 直樹
× 柏村, 直樹× 野間, 誠司× 北川, 優× 出口, 修平× 辻, 淳一× 土井田, 貴子× 稲垣, 穣× 西川, 司朗× 大川, 勝徳 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Inhibitory effect of some 3-O-substituted hexose derivatives on neutrophil adhesion and its oxidative burst were investigated. Adhesion was inhibited by 3-O-lauroyl-D-glucose (1, TK-125), 3-O-lauroyl-D-allose (2) and 3-O-lauroyl-N-allosamine (3), at the consentration of 10⁻⁵M, by 15-100%, as incubated at 37℃ for 30 min in the presence of FMLP, PMA, or PAF. Generation of hydrogen peroxide in the same system was also inhibited by 1, 2, and 3. Several other 3-O-acyl derivatives were shown to exhibit no or less than 20% inhibition at the concentration of 10⁻⁵M. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | C-3位に置換基を有するへキソース誘導体の好中球の細胞接着と活性酸素生成に及ぼす影響が調べられた。好中球が,FMLP,PMA,またはPAFの存在下,タンパク質KLHに37℃,30分の間に接着するin vitroの反応が3-0-ラウロイル-D-グルコース(TK-125),3-0-ラウロイル-D-アロース,およぴ3-0-ラウロイル-D-アロサミンによって,15-100%阻害された。これらの誘導体は,好中球の過酸化水素生成反応も同じ程度に阻害した。同じ糖の濃度で,他の各種C-3置換へキソース誘導体が調べられたが,いずれも阻害率は20%以下か全く活性がなかった。 | |||||
書誌情報 |
三重大学生物資源学部紀要 = The bulletin of the Faculty of Bioresources, Mie University 巻 16, p. 39-44, 発行日 1996-03-01 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0915-0471 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10073846 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 491 | |||||
その他のタイトル | ||||||
en | ||||||
Effect of 3-O-Substituted Hexose Derivatives on the Adhesion of Neutrophil | ||||||
出版者 | ||||||
出版者 | 三重大学生物資源学部 | |||||
ノート | ||||||
Agropedia提供データ | ||||||
資源タイプ(三重大) | ||||||
Departmental Bulletin Paper / 紀要論文 |