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酸化ストレス応答性lncRNAを介した薬物動態制御タンパク質の発現調節機構の解明
http://hdl.handle.net/10076/00020145
http://hdl.handle.net/10076/0002014500ea3ff2-c767-47fc-8004-ded49d46017b
名前 / ファイル | ライセンス | アクション |
---|---|---|
2021RP0061 (221.4 kB)
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Item type | 報告書 / Research Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2022-01-24 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 酸化ストレス応答性lncRNAを介した薬物動態制御タンパク質の発現調節機構の解明 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Analysis on the expression of protein regulating pharmacokinetics via oxidative stress-response IncRNA | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Long-noncoding RNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 酸化ストレス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 薬物トランスポータ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | P-糖蛋白質 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
著者 |
池村, 健治
× 池村, 健治× 奥田, 真弘 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Long-noncoding RNA(IncRNA)は薬の薬効や副作用を規定する薬物トランスポータや薬物代謝酵素の発現調節への関与が指摘されている。本研究では、ヒト小腸上皮細胞において酸化ストレス暴露によりP-糖タンパク(P-gp)の発現量が上昇することを確認し、IncRNAの一種であるCRNDE(Coloretal neoplasia differentially expressed)がP-gpの発現量を調節することを明らかにした。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Long-noncoding RNA (IncRNA) should regulate the expression of drug-metabolizing enzymes and drug transporters, which affect the efficacy and adverse effect of drugs. In the present study, we demonstrated that the expression level of P-glycoprotein(P-gp/MDR1) was increased in human colon carcinoma cell line Caco-2 cell by the exposure of oxidative stress. In addition, the present findings suggested that CRNDE (Colorectal neoplasia differentially expressed), which is a type of IncRNA, regulated the expression of MDR1. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2017年度~2019年度科学研究費補助金(基盤研究(C))研究成果報告書 | |||||
書誌情報 |
発行日 2020-05-13 |
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出版者 | ||||||
出版者 | 三重大学 | |||||
出版者(ヨミ) | ||||||
ミエダイガク | ||||||
科研費番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 17K08411 | |||||
資源タイプ(三重大) | ||||||
Kaken / 科研費報告書 |