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ニコチン酸,ニコチンアミドおよびイソニコチン酸のヒ卜白血病細胞に対する分化誘導
http://hdl.handle.net/10076/15389
http://hdl.handle.net/10076/15389537bf22b-118f-45a3-a4bb-d2fd7461170a
名前 / ファイル | ライセンス | アクション |
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50C17812.pdf (2.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-11-01 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | ニコチン酸,ニコチンアミドおよびイソニコチン酸のヒ卜白血病細胞に対する分化誘導 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nicotinic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nicotinamide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human leukemia cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NAD | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | isonicotinic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | differentiation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
緒方, 進
× 緒方, 進× 井田, 智恵利× 田口, 寛 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have been investigating the effective uses of prevention and treatment of life style-related disease by nicotinic acid and its related compounds. We investigated differentiation- inducing abilities of 23 nicotinic acid-related compounds in two human leukemia cell lines. In this study, We used human myeroidleukemia cells, HL-60 and human erythroleukemia cells, K562. As the results, differentiation to granulocyte ?like cells was induced by nicotinamide, nicotinamide N-oxide, and isonicotinic acid in HL-60 cells. In K562 cells, differentiation to erythroid-like cells was induced by nicotinic acid and isonicotinic acid. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 我々は,ニコチン酸およびその関連化合物による,生活習慣病の予防や治療への有効利用に関する検討を行ってきた。そして,23種類のニコチン酸関連化合物を用いて,2種類の白血病細胞株に対する分化誘導効果について検討を行った。今回の検討では, ヒト急性白血病細胞HL-60とヒト慢性白血病細胞K562を用いた。その結果,HL-60においては,ニコチンアミド,ニコチンアミドN-オキシド,イソニコチン酸において顆粒球様細胞への分化誘導効果が認められた。また,K562においては,ニコチン酸とイソニコチン酸において,赤血球様細胞への分化誘導が認められた。 | |||||
書誌情報 |
三重大学大学院生物資源学研究科紀要 巻 36, p. 53-58, 発行日 2010-03-01 |
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書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12234310 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
en | ||||||
Differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines | ||||||
出版者 | ||||||
出版者 | 三重大学大学院生物資源学研究科 | |||||
資源タイプ(三重大) | ||||||
Departmental Bulletin Paper / 紀要論文 |