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頭頸部腫瘍における蛋白ワクチンによる腫瘍破壊の免疫モニタリング
http://hdl.handle.net/10076/13713
http://hdl.handle.net/10076/13713c80385be-60f8-4583-bb72-c6aecf3a4ee6
名前 / ファイル | ライセンス | アクション |
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30K16833.pdf (292.9 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2014-03-10 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 頭頸部腫瘍における蛋白ワクチンによる腫瘍破壊の免疫モニタリング | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | がんワクチン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 臨床試験 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 免疫モニタリング | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
著者 |
影山, 愼一
× 影山, 愼一× 湯田, 厚司 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 疎水化多糖類プルランとMAGE-A4組換え蛋白の複合体をワクチンとするがんワクチン臨床試験の免疫モニタリング解析を実施した。頭頸部腫瘍を含む16例において6回以上のワクチン反復投与を完了した。MAGE-A4抗体価はELISAでIgG抗体反応解析を行った。ワクチン前の抗体陽性は3例にみられ、自然免疫反応がみられることが判明し、反応が増強するものが1例、陰性例4例では2例が陽性化した。また、MAGE-A4以外への抗原拡大現象が存在することが観察された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Immune reactions in head/neck cancer patients treated with protein vaccine, recombinant MAGE-A4 protein complexed with cholesteryl pullulan, were analyzed. 16 subjects including head/neck cancer patients completed 6 or more vaccination. Humoral IgG responses were analyzed with ELISA assay. 3 patients were positive for MAGE-A4 antibody prior vaccination, suggesting that there exists natural positive immunity in MAGE-A4 antigen positive cancer patients. Among them, MAGE-A4 immunity was augmented in one case. In 4 MAGE-A4 antibody negative patients, 2 converted to MAGE-A4 IgG positive. Spreading of immune reactions other than vaccinated antigen was observed. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 平成21~23年度科学研究費補助金(基盤研究(C))研究成果報告書 | |||||
書誌情報 |
発行日 2012-04-24 |
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フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
Immunomonitoring in head and neck cancer patients treated with protein vaccine through tumor destruction | ||||||
出版者 | ||||||
出版者 | 三重大学 | |||||
科研費番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 21592191 | |||||
資源タイプ(三重大) | ||||||
Kaken / 科研費報告書 |