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In addition, several polymorphisms associated with restenosis after percutaneous coronary intervention, coronary artery spasm, or hypertension have been identified. More recently, a large genetic epidemiological study was performed to identify additional gene polymorphisms that confer susceptibility to cardiovascular diseases, stroke, and other complex diseases. Methods and Results The relationship of 202 polymorphisms in 152 candidate genes to MI, hypertension, ischemic or hemorrhagic stroke, metabolic syndrome, type 2 diabetes mellitus, obesity, or in-stent restenosis were examined in 5,000 unrelated Japanese individuals. Of these, 14 polymorphisms related to MI, 8 to atherothrombotic cerebral infarction, 9 to intracerebral hemorrhage, and 10 to subarachnoid hemorrhage were identified. This information was then used to develop risk diagnosis systems to predict the future risk for development of each disease in a given individual. 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Identification of genetic factors and development of genetic risk diagnosis systems for cardiovascular diseases and stroke
http://hdl.handle.net/10076/2353
http://hdl.handle.net/10076/2353363bbe7b-5ce5-4cf8-a187-70d7fad61a4c
名前 / ファイル | ライセンス | アクション |
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本文 (110.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-02-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Identification of genetic factors and development of genetic risk diagnosis systems for cardiovascular diseases and stroke | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cardiovascular disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Genetics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myocardial infarction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Polymorphism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Stroke | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamada, Yoshiji
× Yamada, Yoshiji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background Polymorphisms of GJA4 and CYBA and of PAI1 and MMP3 are associated with myocardial infarction (MI) in men and women, respectively. In addition, several polymorphisms associated with restenosis after percutaneous coronary intervention, coronary artery spasm, or hypertension have been identified. More recently, a large genetic epidemiological study was performed to identify additional gene polymorphisms that confer susceptibility to cardiovascular diseases, stroke, and other complex diseases. Methods and Results The relationship of 202 polymorphisms in 152 candidate genes to MI, hypertension, ischemic or hemorrhagic stroke, metabolic syndrome, type 2 diabetes mellitus, obesity, or in-stent restenosis were examined in 5,000 unrelated Japanese individuals. Of these, 14 polymorphisms related to MI, 8 to atherothrombotic cerebral infarction, 9 to intracerebral hemorrhage, and 10 to subarachnoid hemorrhage were identified. This information was then used to develop risk diagnosis systems to predict the future risk for development of each disease in a given individual. Conclusions Identification of gene polymorphisms that confer susceptibility to cardiovascular diseases or stroke and the development of genetic risk diagnosis systems may contribute to the personalized prevention of these conditions. | |||||
書誌情報 |
Circulation Journal 巻 70, 号 10, p. 1240-1248, 発行日 2006-09-01 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1346-9843 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11591968 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 16998253 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1253/circj.70.1240 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
出版者 | ||||||
出版者 | Japanese Circulation Society | |||||
関係URI | ||||||
関連名称 | http://www.jstage.jst.go.jp/article/circj/70/10/1240/_pdf | |||||
ノート | ||||||
出版者版電子ジャーナルあり | ||||||
資源タイプ(三重大) | ||||||
Journal Article / 学術雑誌論文 |