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The Effect of Misregistration Between CT-Attenuation and PET-Emission Images in 13N-Ammonia Myocardial PET/CT
http://hdl.handle.net/10076/00017108
http://hdl.handle.net/10076/00017108c61bd2d6-c9f1-4ae3-8916-d646fe83bb46
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2016DM012 (542.2 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2017-11-07 | |||||||||||
| タイトル | ||||||||||||
| タイトル | The Effect of Misregistration Between CT-Attenuation and PET-Emission Images in 13N-Ammonia Myocardial PET/CT | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | cardiac PET/CT | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | image misregistration | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | attenuation correction | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | artifact | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | 13N-ammonia | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
冨田, 陽也
× 冨田, 陽也
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | In 2-dimensional cardiac PET/CT, misregistration between the PET and CT images due to respiratory and cardiac motion causes tracer uptake to appear substantially reduced. The resolution and quality of the images have been considerably improved by the use of 3-dimensional (3D) PET acquisitions. In the current study, we investigated the impact that misregistration between PET and CT images has on myocardial 13N-ammonia uptake in images reconstructed with 3D ordered-subset expectation maximization combined with time-of-flight and point-spread-function modeling. Methods: Eight healthy volunteers (7 men and 1 woman; mean age ± SD, 53 ± 19 y) underwent 13N-ammonia cardiac PET/CT at rest. First, any misregistration between the PET and CT images was manually corrected to generate reference images. Then, the images were intentionally misregistered by shifting the PET images from the reference images by a degree of 1, 2, 3, 4, 5, 10, and 15 mm along both the x-axis (left) and the z-axis (cranial). For each degree of misregistration, the PET images were reconstructed using the CT-attenuation images. The left ventricular short-axis PET/CT images were divided into 4 segments: anterior wall, inferior wall, lateral wall, and septum. The erroneous decrease in myocardial uptake in basal, mid, and apical slices was visually graded using a 4-point scale (0 = none, 1 = mild, 2 = moderate, and 3 = severe). Wall-to-septum uptake ratios were evaluated for the anterior, inferior, and lateral walls in the basal, mid, and apical slices. Results: A statistically significant reduction in myocardial 13N-ammonia uptake in the anterior (P ＜ 0.01) and lateral (P ＜ 0.05) walls was observed when misregistration was 10 mm or more. The uptake ratios for the anterior, lateral, and inferior walls in the reference images were 1.00 ± 0.04, 0.96 ± 0.08, and 0.91 ± 0.03, respectively. The ratios for the anterior and lateral walls significantly decreased when misregistration exceeded 10 mm (anterior wall, 0.80 ± 0.06, P ＜ 0.0001; lateral wall, 0.82 ± 0.07, P ＜ 0.01), whereas the ratio for the inferior wall was relatively small at all 7 degrees of misregistration (0.86 ± 0.05 at 15-mm misregistration, P = 0.06). Conclusion: In PET/CT images reconstructed with 3D ordered-subset expectation maximization combined with time-of-flight and point-spread-function modeling, we found a statistically significant artifactual reduction in tracer uptake in heart regions overlapping lung when misregistration between PET and CT exceeded 10 mm. | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 本文 / Central Division of Radiology, Mie University Hospital | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 6p | |||||||||||
| 書誌情報 |
発行日 2016-09-21 |
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| DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.2967/jnmt.116.172742 | |||||||||||
| フォーマット | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 三重大学 | |||||||||||
| 出版者（ヨミ） | ||||||||||||
| ミエダイガク | ||||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士(医学) | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 14101 | |||||||||||
| 学位授与機関名 | 三重大学 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2016-09-21 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲医学第1799号 | |||||||||||
| ノート | ||||||||||||
| 資源タイプ（三重大） | ||||||||||||
| Doctoral Dissertation / 博士論文 | ||||||||||||
