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Oral administration of L-carnitine improves the clinical outcome of fertility in patients with IVF treatment
http://hdl.handle.net/10076/00018399
http://hdl.handle.net/10076/000183997c99b79b-d9a7-459f-82d7-477bcc2b302f
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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公開日 | 2019-10-15 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Oral administration of L-carnitine improves the clinical outcome of fertility in patients with IVF treatment | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | Fertility treatment | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | free-fatty acids | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | mitochondria | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
資源タイプ | doctoral thesis | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
著者 |
北野, 裕子
× 北野, 裕子
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Age-dependent decline of mitochondrial function has been proposed to be a main cause of decline of embryo quality. Then, L-carnitine plays important roles in reducing the membranous toxicity of free-fatty acids by forming acyl-carnitine and promoting b-oxidation, preventing cell damage. Recent research revealed that L-carnitine played important roles in vitro in oocyte growth, oocyte maturation and embryo development. However, such beneficial effects of L-carnitine in vivo have yet to be verified. The effect of oral L-carnitine supplementation on embryo quality and implantation potential was examined. A total of 214 patients were included in this study. They all previously received in vitro fertilization-embryo transfer (IVF-ET) and failed to conceive. Then they were administered L-carnitine for 82 days on average and underwent IVF-ET again. There were no significant differences in the total number of retrieved oocytes, and their maturation and fertilization rates between before and after L -carnitine administration. The quality of embryos on Days 3 and 5 after insemination was improved following L-carnitine administration (p<.05) in cycles after L-carnitine administration compared with previous cycles. Healthy neonates were born after IVF-ET following L-carnitine administration. Our data suggested that oral administration of L-carnitine to fertility patients improved the developmental competence of their oocytes after insemination. | |||||||||||
内容記述 | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | 本文/Department of Obstetrics and Gynecology, Mie University School of Medicine, Mie, Japan | |||||||||||
内容記述 | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | 6p | |||||||||||
書誌情報 |
発行日 2019-03-25 |
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DOI | ||||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.1080/09513590.2018.1431769 | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | application/pdf | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
出版者 | ||||||||||||
出版者 | 三重大学 | |||||||||||
出版者(ヨミ) | ||||||||||||
ミエダイガク | ||||||||||||
学位名 | ||||||||||||
学位名 | 博士(医学) | |||||||||||
学位授与機関 | ||||||||||||
学位授与機関識別子Scheme | kakenhi | |||||||||||
学位授与機関識別子 | 14101 | |||||||||||
学位授与機関名 | 三重大学 | |||||||||||
学位授与年月日 | ||||||||||||
学位授与年月日 | 2019-03-25 | |||||||||||
学位授与番号 | ||||||||||||
学位授与番号 | 甲医学第1931号 | |||||||||||
ノート | ||||||||||||
GYNECOLOGICAL ENDOCRINOLOGY, 2018に掲載 | ||||||||||||
資源タイプ(三重大) | ||||||||||||
Doctoral Dissertation / 博士論文 |