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Oral administration of L-carnitine improves the clinical outcome of fertility in patients with IVF treatment
http://hdl.handle.net/10076/00018399
http://hdl.handle.net/10076/000183997c99b79b-d9a7-459f-82d7-477bcc2b302f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2018DM0304 (760.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2019-10-15 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Oral administration of L-carnitine improves the clinical outcome of fertility in patients with IVF treatment | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Fertility treatment | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | free-fatty acids | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | mitochondria | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
北野, 裕子
× 北野, 裕子
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Age-dependent decline of mitochondrial function has been proposed to be a main cause of decline of embryo quality. Then, L-carnitine plays important roles in reducing the membranous toxicity of free-fatty acids by forming acyl-carnitine and promoting b-oxidation, preventing cell damage. Recent research revealed that L-carnitine played important roles in vitro in oocyte growth, oocyte maturation and embryo development. However, such beneficial effects of L-carnitine in vivo have yet to be verified. The effect of oral L-carnitine supplementation on embryo quality and implantation potential was examined. A total of 214 patients were included in this study. They all previously received in vitro fertilization-embryo transfer (IVF-ET) and failed to conceive. Then they were administered L-carnitine for 82 days on average and underwent IVF-ET again. There were no significant differences in the total number of retrieved oocytes, and their maturation and fertilization rates between before and after L -carnitine administration. The quality of embryos on Days 3 and 5 after insemination was improved following L-carnitine administration (p<.05) in cycles after L-carnitine administration compared with previous cycles. Healthy neonates were born after IVF-ET following L-carnitine administration. Our data suggested that oral administration of L-carnitine to fertility patients improved the developmental competence of their oocytes after insemination. | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 本文/Department of Obstetrics and Gynecology, Mie University School of Medicine, Mie, Japan | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 6p | |||||||||||
| 書誌情報 |
発行日 2019-03-25 |
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| DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1080/09513590.2018.1431769 | |||||||||||
| フォーマット | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 三重大学 | |||||||||||
| 出版者（ヨミ） | ||||||||||||
| 値 | ミエダイガク | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士(医学) | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 14101 | |||||||||||
| 学位授与機関名 | 三重大学 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2019-03-25 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲医学第1931号 | |||||||||||
| ノート | ||||||||||||
| 値 | GYNECOLOGICAL ENDOCRINOLOGY, 2018に掲載 | |||||||||||
| 資源タイプ（三重大） | ||||||||||||
| 値 | Doctoral Dissertation / 博士論文 | |||||||||||
