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Cognitive Function and Brain Atrophy Predict Non-pharmacological Efficacy in Dementia: The Mihama-Kiho Scan Project2
http://hdl.handle.net/10076/00018401
http://hdl.handle.net/10076/00018401c4f149c3-46c5-470b-a1b0-6da7267c09bb
名前 / ファイル | ライセンス | アクション |
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2018DM0312.pdf (1.1 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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公開日 | 2019-10-16 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Cognitive Function and Brain Atrophy Predict Non-pharmacological Efficacy in Dementia: The Mihama-Kiho Scan Project2 | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | dementia | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | exercise with music | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | cognitive dysfunction | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | voxel-based morphometry | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | atrophy | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | frontal lobe | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
資源タイプ | doctoral thesis | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
著者 |
田部井, 賢一
× 田部井, 賢一
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | We aimed to determine whether neuropsychological deficits and brain atrophy could predict the efficacy of non-pharmacological interventions. Forty-six participants with mild-to-moderate dementia were monitored for 6 months; 25 underwent an intervention involving physical exercise with music, and 21 performed cognitive stimulation tasks. Participants were categorized into improvement (IMP) and no-IMP subgroups. In the exercise-with-music group, the no-IMP subgroup performed worse than the IMP subgroup on the Rivermead Behavioural Memory Test at baseline. In the cognitivestimulation group, the no-IMP subgroup performed worse than the IMP subgroup on Raven’s Colored Progressive Matrices and the cognitive functional independence measure at baseline. In the no-IMP subgroup, voxel-based morphometric analysis at baseline revealed more extensive gray matter loss in the anterior cingulate gyrus and left middle frontal gyrus in the exercise-with-music and cognitive-stimulation groups, respectively. Participants with mild-to-moderate dementia with cognitive decline and extensive cortical atrophy are less likely to show improved cognitive function after non-pharmaceutical therapy. | |||||||||||
内容記述 | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | 本文/Department of Dementia Prevention and Therapeutics, Graduate School of Medicine, Mie University, Tsu, Japan | |||||||||||
内容記述 | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | 7p | |||||||||||
書誌情報 |
発行日 2019-03-25 |
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DOI | ||||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.3389/fnagi.2018.00087 | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | application/pdf | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
出版者 | ||||||||||||
出版者 | 三重大学 | |||||||||||
出版者(ヨミ) | ||||||||||||
ミエダイガク | ||||||||||||
学位名 | ||||||||||||
学位名 | 博士(医学) | |||||||||||
学位授与機関 | ||||||||||||
学位授与機関識別子Scheme | kakenhi | |||||||||||
学位授与機関識別子 | 14101 | |||||||||||
学位授与機関名 | 三重大学 | |||||||||||
学位授与年月日 | ||||||||||||
学位授与年月日 | 2019-03-25 | |||||||||||
学位授与番号 | ||||||||||||
学位授与番号 | 甲医学第1935号 | |||||||||||
ノート | ||||||||||||
Frontiers in Aging Neuroscience 2018; 10; 87に掲載 | ||||||||||||
資源タイプ(三重大) | ||||||||||||
Doctoral Dissertation / 博士論文 |