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  1. 30 大学院医学系研究科・医学部
  2. 30D 学位論文
  3. 博士論文 本文
  4. 2019年度

Prognostic Nutritional Index after Chemoradiotherapy Was the Strongest Prognostic Predictor among Biological and Conditional Factors in Localized Pancreatic Ductal Adenocarcinoma Patients

http://hdl.handle.net/10076/00018455
http://hdl.handle.net/10076/00018455
5a55ea7c-abc8-4e3b-88b3-b92da9b2f624
名前 / ファイル ライセンス アクション
2019DM0708.pdf 2019DM0708.pdf (2.6 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-10-24
タイトル
タイトル Prognostic Nutritional Index after Chemoradiotherapy Was the Strongest Prognostic Predictor among Biological and Conditional Factors in Localized Pancreatic Ductal Adenocarcinoma Patients
言語 en
言語
言語 eng
キーワード
主題Scheme Other
主題 chemoradiation therapy
キーワード
主題Scheme Other
主題 pancreatic ductal adenocarcinoma
キーワード
主題Scheme Other
主題 locally advanced PDAC
キーワード
主題Scheme Other
主題 PNI
キーワード
主題Scheme Other
主題 immunonutritional/inflammatory markers
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 市川, 健

× 市川, 健

en Ichikawa, Ken

ja-Kana イチカワ, ケン

ja 市川, 健

Search repository
抄録
内容記述タイプ Abstract
内容記述 Background: In many malignancies, including pancreatic ductal adenocarcinoma (PDAC), host-related inflammatory/immunonutritional markers, such as the prognostic nutritional index (PNI), modified Glasgow prognostic score (mGPS), and C-reactive protein (CRP)/albumin ratio are reported to be prognostic factors. However, the prognostic influence of these factors before and after chemoradiotherapy (CRT) has not been studied in PDAC patients. Methods: Of 261 consecutive PDAC patients who were scheduled for CRT with gemcitabine or S1 plus gemcitabine between February 2005 and December 2015, participants in this study were 176 who completed CRT and had full data available on inflammatory/immunonutritional markers as well as on anatomical and biological factors for the investigation of prognostic/predictive factors. Results: In multivariate analysis, the significant prognostic factors were RECIST classification, cT category, performance status, post-CRT carcinoembryonic antigen, post-CRT C-reactive protein/albumin ratio, post-CRT mGPS, and post-CRT PNI. Post-CRT PNI (cut-o value, 39) was the strongest host-related prognostic factor according to the p-value. In the patients who underwent resection after CRT, median survival time (MST) was significantly shorter in the 12 patients with low PNI (<39) than in the 97 with high PNI (≥39), at 15.5 months versus 27.2 months, respectively (p = 0.0016). In the patients who did not undergo resection, MST was only 8.9 months in those with low PNI and 12.3 months in those with high PNI (p < 0.0001), and thus was similar to that of the resected patients with low PNI. Conclusions: Post-CRT PNI was the strongest prognostic/predictive indicator among the independent biological and conditional prognostic factors in PDAC patients who underwent CRT.
内容記述
内容記述タイプ Other
内容記述 本文/Hepatobiliary Pancreatic and Transplant Surgery, Mie University School of Medicine, 2-174 Edobashi, Tsu,
Mie 514-8507, Japan
内容記述
内容記述タイプ Other
内容記述 19p
書誌情報
発行日 2019-07-17
DOI
識別子タイプ DOI
関連識別子 10.3390/cancers11040514
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 三重大学
出版者(ヨミ)
値 ミエダイガク
学位名
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 14101
学位授与機関名 三重大学
学位授与年月日
学位授与年月日 2019-07-17
学位授与番号
学位授与番号 甲医学第1965号
ノート
資源タイプ(三重大)
値 Doctoral Dissertation / 博士論文
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