{"_buckets": {"deposit": "b964b43f-ca64-45f7-9524-37a87c9e9bc3"}, "_deposit": {"created_by": 15, "id": "13279", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "13279"}, "status": "published"}, "_oai": {"id": "oai:mie-u.repo.nii.ac.jp:00013279", "sets": ["1692684750464"]}, "author_link": ["43221", "43222", "43223", "43224", "43225", "43216", "43217", "43218", "43219", "43220", "43211", "43212", "43213", "43214", "43215"], "item_8_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-05-29", "bibliographicIssueDateType": "Issued"}}]}, "item_8_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "DOHI, Kaoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "43221", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ITO, Masaaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "43222", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YAMADA, Norikazu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "43223", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "FUJIMOTO, Naoki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "43224", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NAKAMORI, Shiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "43225", "nameIdentifierScheme": "WEKO"}]}]}, "item_8_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_8_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "心不全で入院し心臓カテーテル検査を受けた32名のうち、受動性後毛細血管性肺高血圧症（Passive pc-PH）群 9名、反応性後毛細血管性肺高血圧症（Reactive pc-PH）群 6名にRho キナーゼ阻害薬であるFasudilを1 mg/min で30 分間投与した。Passive pc-PH群では、全身血管抵抗は低下したが、肺血管抵抗に変化は認められなかった。Reactive pc-PH群では、肺血管抵抗・全身血管抵抗ともに低下傾向を認めたが、統計学的有意差には至らなかった。両群で心係数は有意に増加した。以上より病態の違いによるRho キナーゼ阻害薬に対する反応性の差異が示唆された。", "subitem_description_type": "Abstract"}, {"subitem_description": "Thirty-two heart failure patients who underwent cardiac catheter evaluation were recruited in the present study, and 9 patients were categorized as passive post-capillary pulmonary hypertension (pc-PH) and 6 patients were categorized as reactive pc-PH. They receive continuous infusion of Fasudil, a Rho-kinase inhibitor, with 1ml/min for 30 minutes. In patients with passive pc-PH, Fasudil significantly reduced systemic vascular resistance (SVR) but not pulmonary vascular resistance (PVR). On the other hand, Fasudil tended to reduce both SVR and PVR. Fasudil significantly increased cardiac output in the both patient groups. These results indicate that RhoA/Rho-kinase plays an important role in the regulation of pulmonary and systemic vascular tone in patients with pc-PH, whereas passive and reactive pc-PH has different response to Rho-kinase inhibitor.", "subitem_description_type": "Abstract"}]}, "item_8_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "2015年度～2017年度科学研究費補助金(基盤研究(C))研究成果報告書", "subitem_description_type": "Other"}]}, "item_8_description_64": {"attribute_name": "科研費番号", "attribute_value_mlt": [{"subitem_description": "15K09079", "subitem_description_type": "Other"}]}, "item_8_full_name_2": {"attribute_name": "著者（ヨミ）", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "43216", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ドヒ, カオル", "nameLang": "ja-Kana"}]}, {"nameIdentifiers": [{"nameIdentifier": "43217", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "イトウ, マサアキ", "nameLang": "ja-Kana"}]}, {"nameIdentifiers": [{"nameIdentifier": "43218", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ヤマダ, ノリカズ", "nameLang": "ja-Kana"}]}, {"nameIdentifiers": [{"nameIdentifier": "43219", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "フジモト, ナオキ", "nameLang": "ja-Kana"}]}, {"nameIdentifiers": [{"nameIdentifier": "43220", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "ナカモリ, シロウ", "nameLang": "ja-Kana"}]}]}, "item_8_publisher_30": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "三重大学"}]}, "item_8_text_31": {"attribute_name": "出版者（ヨミ）", "attribute_value_mlt": [{"subitem_text_value": "ミエダイガク"}]}, "item_8_text_65": {"attribute_name": "資源タイプ（三重大）", "attribute_value_mlt": [{"subitem_text_value": "Kaken / 科研費報告書"}]}, "item_8_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "土肥, 薫", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "43211", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "伊藤, 正明", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "43212", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田, 典一", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "43213", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤本, 直紀", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "43214", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中森, 史朗", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "43215", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-01-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "2019RP0053.pdf", "filesize": [{"value": "429.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 429500.0, "url": {"label": "2019RP0053", "url": "https://mie-u.repo.nii.ac.jp/record/13279/files/2019RP0053.pdf"}, "version_id": "2d1257d6-f794-455e-aa7e-896444b667b0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "左心系心疾患", "subitem_subject_scheme": "Other"}, {"subitem_subject": "肺高血圧症", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "左心系疾患による肺高血圧症進展のメカニズム解明および治療ターゲットの創出", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "左心系疾患による肺高血圧症進展のメカニズム解明および治療ターゲットの創出", "subitem_title_language": "ja"}, {"subitem_title": "Assessment of RhoA/Rho-kinase-mediated regulation of pulmonary arterial vascular tone as a potential therapeutic target in patients with pulmonary hypertension with left heart disease", "subitem_title_language": "en"}]}, "item_type_id": "8", "owner": "15", "path": ["1692684750464"], "permalink_uri": "http://hdl.handle.net/10076/00018898", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2020-01-22"}, "publish_date": "2020-01-22", "publish_status": "0", "recid": "13279", "relation": {}, "relation_version_is_last": true, "title": ["左心系疾患による肺高血圧症進展のメカニズム解明および治療ターゲットの創出"], "weko_shared_id": -1}