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アイテム
Immunohistochemical expression and clinicopathological assessment of the cancer testis antigens NY‑ESO‑1 and MAGE‑A4 in high‑grade soft‑tissue sarcoma
http://hdl.handle.net/10076/00018955
http://hdl.handle.net/10076/000189550a437327-772f-4ec6-b665-cd5e26a6676f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2019DM1218.pdf (3.5 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2020-02-04 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Immunohistochemical expression and clinicopathological assessment of the cancer testis antigens NY‑ESO‑1 and MAGE‑A4 in high‑grade soft‑tissue sarcoma | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | New York‑esophageal squamous cell carcinoma‑1 | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | melanoma‑associated antigen‑4 | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | high grade soft tissue sarcoma | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | cancer testis antigens | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | synovial sarcoma | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
柿本, 拓也
× 柿本, 拓也
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | The aim of the present study was to explore the expression of the cancer testis antigens New York‑esophageal squamous cell carcinoma (NY‑ESO) ‑1 and melanoma‑associated antigen (MAGE)‑A4 in high‑grade soft‑tissue sarcoma and to evaluate their association with the standard clinical‑pathological features of surgically treated high‑grade sarcoma patients. The study included 82 patients, and NY‑ESO‑1 and MAGE‑A4 antigen expression was analyzed immunohistochemically. The results revealed NY‑ESO‑1‑ and MAGE‑A4‑positive staining in 58.8 and 52.9% of synovial sarcomas, and 55.6 and 0% of myxoid liposarcomas, respectively. In patients with synovial sarcoma, NY‑ESO‑1 and MAGE‑A4 were expressed in 7 patients, onlyNY‑ESO‑1 was expressed in 3 patients, and only MAGE‑A4was expressed in 2 patients. Univariate analysis indicated that a significantly higher MAGE‑A4 expression was observed in younger patients (P<0.001) and those with synovial sarcoma(P<0.001). Multivariate analysis indicated that significantly higher NY‑ESO‑1 expression was observed in patients with synovial sarcoma (P<0.01) and myxoid liposarcoma(P<0.01), and significantly higher MAGE‑A4 expression was observed in patients with synovial sarcoma (P<0.01). In high‑grade sarcomas, the 2‑ and 5‑year overall survival rates based on Kaplan‑Meier estimates were 100 and 81.3% in the NY‑ESO‑1‑positive group, and 69.7 and 53.0% in the NY‑ESO‑1‑negative group, respectively (P=0.049). It was also demonstrated that either NY‑ESO‑1 or MAGE‑A4 was positive in 70.6% of synovial sarcomas. These results indicate that NY‑ESO‑1 and MAGE‑A4 may be useful for the diagnosis of synovial sarcoma. The independent expression of NY‑ESO‑1and MAGE‑A4, which may help expand the pool of candidates for molecular‑targeted immunotherapy, will be beneficial for synovial sarcoma patients. | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 本文/Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Mie 514‑8507 | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 7p | |||||||||||
| 書誌情報 |
発行日 2019-12-18 |
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| DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.3892/ol.2019.10044 | |||||||||||
| フォーマット | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 三重大学 | |||||||||||
| 出版者（ヨミ） | ||||||||||||
| 値 | ミエダイガク | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士(医学) | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 14101 | |||||||||||
| 学位授与機関名 | 三重大学 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2019-12-18 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 乙医学第1046号 | |||||||||||
| ノート | ||||||||||||
| 値 | ONCOLOGY LETTERS 2019;17:3937-3943に掲載 | |||||||||||
| 資源タイプ（三重大） | ||||||||||||
| 値 | Doctoral Dissertation / 博士論文 | |||||||||||
