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  1. 30 大学院医学系研究科・医学部
  2. 30K 科研費報告書
  3. 2019年度

前立腺癌細胞分化の揺らぎによる去勢抵抗性獲得機構

http://hdl.handle.net/10076/00019465
http://hdl.handle.net/10076/00019465
8027842c-7c4e-4b69-9504-0d5505b0e0e1
名前 / ファイル ライセンス アクション
2020RP0028.pdf 2020RP0028 (123.1 kB)
Item type 報告書 / Research Paper(1)
公開日 2020-11-12
タイトル
言語 ja
タイトル 前立腺癌細胞分化の揺らぎによる去勢抵抗性獲得機構
タイトル
言語 en
タイトル Mechanisms for development of castration resistance by fluctuation of the differentiation in human prostate cancer cells
言語
言語 jpn
キーワード
主題Scheme Other
主題 去勢抵抗性前立腺癌
キーワード
主題Scheme Other
主題 ホルモン療法
キーワード
主題Scheme Other
主題 癌細胞分化
キーワード
主題Scheme Other
主題 線維芽細胞の多様性
キーワード
主題Scheme Other
主題 前立腺癌患者由来線維芽細胞
キーワード
主題Scheme Other
主題 in vitro共培養実験
キーワード
主題Scheme Other
主題 癌抑制遺伝子
キーワード
主題Scheme Other
主題 癌遺伝子
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_18ws
資源タイプ research report
著者 石井, 健一朗

× 石井, 健一朗

WEKO 45263

ja 石井, 健一朗

Search repository
広川, 佳史

× 広川, 佳史

WEKO 45264

ja 広川, 佳史

Search repository
杉村, 芳樹

× 杉村, 芳樹

WEKO 45265

ja 杉村, 芳樹

Search repository
白石, 泰三

× 白石, 泰三

WEKO 45266

ja 白石, 泰三

Search repository
著者(ヨミ)
姓名 イシイ, ケンイチロウ
言語 ja-Kana
著者(ヨミ)
姓名 ヒロカワ, ヨシフミ
言語 ja-Kana
著者(ヨミ)
姓名 スギムラ, ヨシキ
言語 ja-Kana
著者(ヨミ)
姓名 シライシ, タイゾウ
言語 ja-Kana
著者別名 Ishii, Kenichiro

× Ishii, Kenichiro

WEKO 45271

en Ishii, Kenichiro

Search repository
HIROKAWA, yoshifumi

× HIROKAWA, yoshifumi

WEKO 45272

en HIROKAWA, yoshifumi

Search repository
SUGIMURA, yoshiki

× SUGIMURA, yoshiki

WEKO 45273

en SUGIMURA, yoshiki

Search repository
SHIRAISHI, taizo

× SHIRAISHI, taizo

WEKO 45274

en SHIRAISHI, taizo

Search repository
抄録
内容記述タイプ Abstract
内容記述 去勢抵抗性前立腺癌への進展機構としてホルモン療法後に生じる癌間質構造の多様性に着目した。癌間質を構成するactiveな線維芽細胞は細胞増殖因子やサイトカイン、細胞外マトリックスの構築などを介し、前立腺癌の悪性・進展を促進させる。ひと前立腺癌患者由来線維芽細胞とヒト前立腺癌細胞をin vitro共培養したところ、いくつかの線維芽細胞は癌細胞における癌抑制遺伝子の発現量を有意に低下させた。一方で、癌遺伝子の発現量を有意に増加させる線維芽細胞も確認された。つまり、activeな線維芽細胞は癌細胞の増殖に関わるだけでなく、癌細胞の分化状態をも変化させ、去勢抵抗性の獲得に寄与している可能性が示唆された。
抄録
内容記述タイプ Abstract
内容記述 In the tumor microenviroment, heterogeneous stromal component of prostate cancer (PCa) tissue contains multiple populations of fibroblasts that are associated with tumorigenesis. Fibroblasts secret a number of growth factors, cytokines, ECM proteins, and miRNAs that stimulate progression of PCa cells. In this study, we investigated the effects of fibroblasts on androgen-sensitive human PCa cell line LNCaP focusing on the expression of cancer-related genes. As for tumor suppressor genes, mRNA expression of NKX3-1 in LNCaP cells was decreased by co-culturing with fibroblasts. As for oncogenes, mRNA expressions of NFKB1 and SRC in LNCap cells was increased by co-culturing with fibroblasts. Our data showed that mRNA expressions of cancer-related genes in LNCaP cells were highly disturbed by co-culturing with fibroblasts. The use of PCa patients-derived fibroblasts may allow us to investigate the characteristics of aggressive fibroblasts in the development of castration-resistant PCa.
内容記述
内容記述タイプ Other
内容記述 2016年度~2018年度科学研究費補助金(基盤研究(C))研究成果報告書
書誌情報
発行日 2019-05-20
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 三重大学
出版者(ヨミ)
ミエダイガク
科研費番号
内容記述タイプ Other
内容記述 16K11000
資源タイプ(三重大)
Kaken / 科研費報告書
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