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Ganglioside GD2 Expression Is Associated With Unfavorable Prognosis in Early Triple-negative Breast Cancer
http://hdl.handle.net/10076/0002000778
http://hdl.handle.net/10076/000200077835efbcf1-4569-4d7c-9a80-1e17f364a1b4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
2023DM0338.pdf (2.3 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||||
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| 公開日 | 2024-05-14 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Ganglioside GD2 Expression Is Associated With Unfavorable Prognosis in Early Triple-negative Breast Cancer | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | GD2 | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | triple-negative breast cancer | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | tumor infiltrating lymphocytes (TILs) | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | prognosis | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | early-stage | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||||
| 資源タイプ | doctoral thesis | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 著者 |
東, 千尋
× 東, 千尋
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Background/Aim: Gangliosides (acidic glycosphingolipids) have crucial regulatory roles in normal physiological processes, as well as in pathological conditions, including tumor onset and progression. GD2 is highly expressed in triple-negative breast cancer (TNBC), particularly in cancer stem cells. However, little is known on the clinical impact of GD2 expression on the prognosis of TNBC. Consequently, we aimed to investigate the association between GD2 expression in TNBC and the prognosis of TNBC. Patients and Methods: We assessed GD2 expression in 76 patients with primary TNBC who had undergone surgery at our Institute between 2012 and 2015 using immunohistochemical analysis with a tissue microarray technique. We investigated the relationship between GD2 expression and clinicopathological factors in TNBC, recurrence free survival (RFS), and overall survival (OS). Results: Increased GD2 expression was observed in 45% of TNBC patients. There was no significant association between GD2 expression and clinicopathological factors in TNBC. The 5-year RFS rate among patients with GD2-positive TNBCs was significantly worse than that among patients with GD2-negative TNBCs (75.4% and 94.9%; HR=4.931; 95%CI=1.024-23.752; p=0.027). The OS in patients with GD2-positive TNBCs tended to be inferior to that of patients with GD2-negative TNBCs (HR=5.357; 95%CI=0.599-47.939; p=0.092). Interestingly, in patients with GD2-positive TNBCs, a higher grade of tumorinfiltrating lymphocytes (TILs) displayed a significantly better impact on OS (TILs-high vs. TILs-low; p=0.04). Both univariate and multivariate analyses showed that GD2 expression negatively affected RFS (p=0.027, p=0.021, respectively). Conclusion: GD2 expression is an independent unfavorable prognostic factor for TNBC. | |||||||||||||
| 言語 | en | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | 本文/Department of Breast Surgery, Mie University Graduate School of Medicine, Mie, Japan | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | 9p | |||||||||||||
| 書誌情報 |
発行日 2024-03-25 |
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| DOI | ||||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.21873/anticanres.16593 | |||||||||||||
| フォーマット | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | 三重大学 | |||||||||||||
| 出版者（ヨミ） | ||||||||||||||
| 値 | ミエダイガク | |||||||||||||
| 学位名 | ||||||||||||||
| 学位名 | 博士(医学) | |||||||||||||
| 学位授与機関 | ||||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||||
| 学位授与機関識別子 | 14101 | |||||||||||||
| 学位授与機関名 | 三重大学 | |||||||||||||
| 学位授与年月日 | ||||||||||||||
| 学位授与年月日 | 2024-03-25 | |||||||||||||
| 学位授与番号 | ||||||||||||||
| 学位授与番号 | 甲医学第2251号 | |||||||||||||
| ノート | ||||||||||||||
| 資源タイプ（三重大） | ||||||||||||||
| 値 | Doctoral Dissertation / 博士論文 | |||||||||||||
