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  1. 30 大学院医学系研究科・医学部
  2. 30D 学位論文
  3. 博士論文 本文
  4. 2024年度

Endplate and intervertebral disc injuries in acute and single level osteoporotic vertebral fractures: is there any association with the process of bone healing?

http://hdl.handle.net/10076/0002000844
http://hdl.handle.net/10076/0002000844
10f0e19b-1555-48ad-b2ad-e6a2c03e782b
名前 / ファイル ライセンス アクション
2024DM0714.pdf 2024DM0714.pdf
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2024-07-30
タイトル
タイトル Endplate and intervertebral disc injuries in acute and single level osteoporotic vertebral fractures: is there any association with the process of bone healing?
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Endplate injury
キーワード
言語 en
主題Scheme Other
主題 Intervertebral disc injury
キーワード
言語 en
主題Scheme Other
主題 Osteoporosis
キーワード
言語 en
主題Scheme Other
主題 Vertebral fracture
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 藤原, 達彦

× 藤原, 達彦

ja 藤原, 達彦

ja-Kana フジワラ, タツヒコ

en Fujiwara, Tatsuhiko

Search repository
抄録
内容記述タイプ Abstract
内容記述 Background: The endplate-intervertebral disc (IVD) complex is closely interrelated with the vertebral body (VB) in the structural integrity of the anterior spinal column, including biomechanical and biological functions. Endplate and IVD injuries are usually found in association with vertebral fractures (VFs); however, little is known about their relevance to the healing of osteoporotic VFs (OVFs). The first purpose of this study was to evaluate the incidence and occurrence pattern of endplate and IVD injuries associated with single- and acute-OVFs, and the second was to evaluate the influence of endplate and IVD injuries on the occurrence of delayed union.
Methods: Endplate and IVD injuries associated with single- and acute-OVFs were retrospectively evaluated using magnetic resonance imaging (MRI). Vertebrae of 168 patients were included in the study. The occurrence rate and type of endplate and IVD injuries were radiologically evaluated, and the association between endplate and IVD injuries was statistically analyzed. Vertebrae of 85 patients, who received conservative treatment for acute OVFs, were included in the study and classified into two groups, union and delayed union, at 6 months after injury. To identify factors predicting delayed union, uni- and multivariate statistical analyses were performed. Vertebral MRI signal alternation patterns and endplate and IVD injuries were included as candidate factors in the logistic model.
Results: In association with OVFs, endplate injuries were observed in 103 of the 168 vertebrae (61%), and IVDs lesions were observed in 101 of 168 OVFs (60%); the occurrence of both injuries was significantly associated. Although no significant association with endplate and IVD injuries was identified, multivariate analysis demonstrated that intravertebral signal alternation (focal high signal intensity) and posterior wall injury were independent risk factors that predicted delayed union.
Conclusions: The results of this study showed that endplate and IVD injuries were found in approximately 60% of single and acute OVFs. These results suggest that fracture healing of OVFs would be mainly attributed to vertebral factors, including mechanical stress and metabolic status, among the three components of the anterior spinal column.
内容記述
内容記述タイプ Other
内容記述 本文/Department of Orthopaedic Surgery, Murase Hospital, 3-12-10 Kanbe, Suzuka City, Mie 514-0801, Japan
内容記述
内容記述タイプ Other
内容記述 11p
書誌情報
発行日 2024-07-17
DOI
識別子タイプ DOI
関連識別子 10.1186/s12891-019-2719-5
フォーマット
内容記述タイプ Other
内容記述 application/pdf
出版者
出版者 三重大学
出版者(ヨミ)
値 ミエダイガク
学位名
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 14101
学位授与機関名 三重大学
学位授与年月日
学位授与年月日 2024-07-17
学位授与番号
学位授与番号 乙医学第1102号
ノート
資源タイプ(三重大)
値 Doctoral Dissertation / 博士論文
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