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正常および糖代謝異常妊婦における赤血球インスリン受容体の解析
http://hdl.handle.net/10076/2791
http://hdl.handle.net/10076/279112d783ca-98b2-4592-86a3-0a6b22df1143
| 名前 / ファイル | ライセンス | アクション |
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本文 (836.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2007-03-29 | |||||||||
| タイトル | ||||||||||
| タイトル | 正常および糖代謝異常妊婦における赤血球インスリン受容体の解析 | |||||||||
| 言語 | ja | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
豊田, 長康
× 豊田, 長康
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Insulin receptors on erythrocytes were studied in normal and diabetic pregnant women to clarify the mechanism of insulin resistance in pregnancy. The assays of insulin receptors were performed according to the method of Kobayashi, which is a slight modification of the method of Gambhir. ¹²⁵I-insulin binding showed no significant differences between normal pregnant women during the first (n=18), the second (n=15) and the third (n=54) trimesters and nonpregnant controls (n=52). There were also no significant differences between the values before and after delivery (n=8). Reticulocyte counts significantly increased in pregnant women during the second trimester and during the later periods. There was a positive correlation between ¹²⁵I-insulin binding and reticulocyte counts in late pregnancy. These findings suggest that reticulocyte counts should always be considered in estimating erythrocyte insulin receptors in pregnancy. Then, insulin binding in late pregnant women with reticulocyte counts below 10% (n=20) was studied. The value was slightly decreased as compared to that in the nonpregnant controls, but difference was not significant. ¹²⁵I-insulin binding in gestational diabetes (n=6) was decreased, but that in overt diabetes (n=4) was not. Patients with overt diabetes had been receiving insulin therapy. Insulin resistance in normal pregnancy cannot be explained by the changes of insulin receptors from this study. It may be due to some post-receptor abnormalities. But decreased insulin binding might be one of the factors that manifest or deteriorate gestational diabetes. |
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| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | 正常および糖代謝異常妊婦における赤血球インスリン受容体の解析 | |||||||||
| 書誌情報 |
日本内分泌学会雑誌 巻 59, 号 2, p. 182-195, 発行日 2007-03-29 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0029-0661 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AN00195891 | |||||||||
| PubMed番号 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 6852301 | |||||||||
| 権利 | ||||||||||
| 権利情報 | 日本内分泌学会 | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 日本十進分類法 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| その他のタイトル | ||||||||||
| 値 | Erythrocyte insulin receptors from normal and diabetic pregnant women | |||||||||
| 出版者 | ||||||||||
| 出版者 | Department of Obstetrics and Gynecology Mie University School of Medicine | |||||||||
| 著作の一部 | ||||||||||
| 値 | http://hdl.handle.net/10076/7538 | |||||||||
| 資源タイプ（三重大） | ||||||||||
| 値 | Journal Article / 学術雑誌論文 | |||||||||
