| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2007-05-11 |
| タイトル |
|
|
タイトル |
鼻過敏性とニューロペプチド |
|
言語 |
ja |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
hyperresposiveness |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
neurooeptide |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
allergic rhinitis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
substance P |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
間島, 雄一
原田, 輝彦
郭, 永清
趙, 重生
坂倉, 康夫
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
鼻アレルギー患者における鼻過敏性の亢進には知覚神経線維を介した順行性の知覚刺激伝達の亢進と,軸索反射により局所に遊離されたSP等のNANC作動神経ペプチドの働きが関与しているものと考えた |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Immunohistochemical staining combined with electron microscopy was employed to investigate the distribution of substance P-immunoreactive (SP-IR) nerve fibers in the tracheal submucosal glands of cats. All the intraglandular varicosities were observed to be in close spatial contact with serous cells, mucous cells and myoepithelial cells. These findings suggesed that SP-induced mucus secretion by airway submucosal glands may be caused not only by glandular contraction, but by direct stimulation of both serous and mucous cells. The distribution of nonadrenergic noncholinergic (NANC) neuropeptides in serous and mucous glands of the nasal mucosa were quantitatively determined in patients with allergic rhinitis (AR) and in patieuts with hypertrophic rhinitis (HR) as a control. The distribution of SP-IR nerve fibers in the serous glands was significantly higher in AR than in HR. The distribution of calcitonin gene-related polypeptide (CGRP) -IR nerve fibers was also signiflcantly higher in both serous and mucous glands in AR. These findings suggest that transmission of nociceptive sensations by NANC neuropeptides may be enhanced in patients with AR, and this could reflect nasal hyperresponsiveness in AR. In the thiorphan pre-treated normal human nose, the topical application of SP significantly decreased histamine concentrations, the initial cause of sneezing, when compared with topical saline administration. The results obtained in these studies suggest that NANC neuropeptides could contribute to nasal hyperresponsiveness via orthodromic and/or antidromic effects. |
| 書誌情報 |
日本鼻科学会会誌
巻 34,
号 2,
p. 393-398,
発行日 1996-03-01
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0910-9153 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00062865 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| その他のタイトル |
|
|
値 |
Nasal hyperresponsiveness and neuropeptide |
| 出版者 |
|
|
出版者 |
日本鼻科学会 |
| 資源タイプ（三重大） |
|
|
値 |
Journal Article / 学術雑誌論文 |
AN000628650340201.pdf (618.9 kB)
