| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2007-12-10 |
| タイトル |
|
|
タイトル |
Loss of hippocampal CA3 phramidal neurons in mice lacking STAM1 |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Yamada, Mitsuhiro
Takeshita, Toshikazu
Miura, Shigeto
Murata, Kazuko
Kimura, Yutaka
Ishii, Naoto
Nose, Masato
Sakagami, Hiroyuki
Kondo, Hisatake
Tashiro, Fumi
Miyazaki, Jun-ichi
Sasaki, Hidetada
Sugamura, Kazuo
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
STAM1, a member of the STAM (signal transducing adapter molecule) family, has a unique structure containing a Src homology 3 domain and ITAM (immunoreceptor tyrosine-based activation motif). STAM1 was previously shown to be associated with the Jak2 and Jak3 tyrosine kinases and to be involved in the regulation of intracellular signal transduction mediated by interleukin-2 (IL-2) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in vitro. Here we generated mice lacking STAM1 by using homologous recombination with embryonic stem cells. STAM1/ mice were morphologically indistinguishable from their littermates at birth. However, growth retardation in the third week after birth was observed for the STAM1/ mice. Unexpectedly, despite the absence of STAM1, hematopoietic cells, including T- and B-lymphocyte and other hematopoietic cell populations, developed normally and responded well to several cytokines, including IL-2 and GM-CSF. However, histological analyses revealed the disappearance of hippocampal CA3 pyramidal neurons in STAM1/ mice. Furthermore, we observed that primary hippocampal neurons derived from STAM1/ mice are vulnerable to cell death induced by excitotoxic amino acids or an NO donor. These data suggest that STAM1 is dispensable for cytokine-mediated signaling in lymphocytes but may be involved in the survival of hippocampal CA3 pyramidal neurons. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
抗酸化系遺伝子改変動物を用いた母体糖尿病による胎児異常発生抑止効果に関する研究 |
| 書誌情報 |
Molecular and cellular biology
巻 21,
号 11,
p. 3807-3819,
発行日 2001-06-01
|
| ISSN |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0270-7306 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10620925 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1128/MCB.21.11.3807-3819.2001 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 出版者 |
|
|
出版者 |
American Society for Microbiology |
| 関係URI |
|
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|
関連名称 |
http://mcb.asm.org/cgi/reprint/21/11/3807 |
| 著作の一部 |
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|
値 |
http://hdl.handle.net/10076/7579 |
| ノート |
|
|
値 |
出版者版電子ジャーナルあり |
| 資源タイプ（三重大） |
|
|
値 |
Journal Article / 学術雑誌論文 |
30A1671.pdf (15.2 MB)
