| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2008-03-11 |
| タイトル |
|
|
タイトル |
Hot-Water Extracts from Adzuki Beans (Vigna angularis) Suppress Not Only the Proliferation of KATO III Cells in Culture but Also Benzo(a)pyrene-Induced Tumorigenesis in Mouse Forestomatch |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
adzuki beans (Vigna angularis) |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cultured KATO III cells |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
benzo(a)pyreneinduced forestomach cancer |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
antitumorigenicity |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
ITOH, Tomohiro
ITOH, Yuko
MIZUTANI, Mineo
FUJISHIRO, Katsuhisa
FURUICHI, Yukio
KOMIYA, Takashi
HIBASAMI, Hiroshige
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Treatment of human stomach cancer KATO III cells with hot-water extracts from adzuki beans led to their growth inhibition as well as apoptosis induction. There are morphological changes in the cultured cells treated with the extracts, by which DNA fragmentation characteristic of apoptosis was actualized both concentration- and time-dependently. In contrast, N-acetyl-L-cysteine suppressed such DNA fragmentation, implying that the extracts from adzuki beans might exert antitumorigenicity via active oxygen-induced apoptosis. In order to verify this hypothesis in animal experiment, the 40% ethanol fraction of hot-water extracts was examined for its preventive effect against benzo(a)pyrene-induced tumorigenesis in the forestomach of A/J mice, given as drinking water containing the above fraction at 0.5-2.0% levels. Consequently, forestomach cancer has turned out to be reduced by 36-62% in tumor weight relative to the control. These results suggest that the fraction of hot-water adzuki extracts may serve as a nutrapharmaceutical or functional food available for cancer prevention. |
| 書誌情報 |
Journal of nutritional science and vitaminology
巻 50,
号 4,
p. 295-299,
発行日 2004-08-01
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0301-4800 |
| 書誌レコードID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00703822 |
| 権利 |
|
|
権利情報 |
日本ビタミン学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきCiNiiから複製したものである |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 出版者 |
|
|
出版者 |
University of Tokyo Press |
| 関係URI |
|
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|
関連名称 |
http://ci.nii.ac.jp/naid/110002704003/ |
| 資源タイプ（三重大） |
|
|
値 |
Journal Article / 学術雑誌論文 |
30A6692.pdf (920.5 kB)
