| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-04-20 |
| タイトル |
|
|
タイトル |
Administration of Ag85B showed therapeutic effects to Th2-type cytokine-mediated acute phase atopic dermatitis by inducing regulatory T cells |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Mori, Hitoshi
Yamanaka, Keiichi
Matsuo, Kazuhiro
Kurokawa, Ichiro
Yasutomi, Yasuhiro
Mizutani, Hitoshi
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Increase in the number of patients with atopic dermatitis (AD) has been recently reported. T helper (Th) cells that infiltrate AD skin lesions are Th2-type dominant; reduced exposure to environmental Th1-cytokine-inducing microbes is believed to contribute to the increased number of AD patients. Regulatory type immune responses have been also associated with the occurrence of AD. It has been reported that antigen 85B (Ag85B) purified from mycobacteria is a potent inducer of Th1-type immune response in mice as well as in humans. In this study, we have examined the effect of plasmid DNA encoding Ag85B derived from Mycobacterium kansasii on AD skin lesions induced by oxazolone (OX) application. Th2-cytokine mediated mouse AD model with immediate type response followed by a late phase reaction was developed by repeated applications of low-dose OX to sensitized mice. Mice were immunized with plasmid DNA encoding cDNA of Ag85B before OX sensitization or during repeated elicitation phase. Both therapies were associated with significant suppression of immediate type response, clinical appearance, dermal cell infiltration, reduced IL-4 production, and augmented IFN-gamma mRNA expression compared to placebo-treated mice. Additionally, increased number of Foxp3(+) regulatory T cells were observed in the skin sections in Ag85B treated mice. The results of this study suggest that Ag85B DNA vaccine is a potential therapy for Th2 type dermatitis. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
アトピー性皮膚炎に対する標的特異的変異型サイトカイン療法の有効性の検討 |
| 書誌情報 |
Archives of dermatological research
巻 301,
号 2,
p. 151-157,
発行日 2009-02-01
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1432-069X |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA0054724X |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
18633632 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s00403-008-0873-y |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 出版者 |
|
|
出版者 |
Springer |
| 著作の一部 |
|
|
値 |
http://hdl.handle.net/10076/10172 |
| 資源タイプ（三重大） |
|
|
値 |
Journal Article / 学術雑誌論文 |
mizutani_3.pdf (3.4 MB)
