| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-12-08 |
| タイトル |
|
|
タイトル |
Effects of various post-treatment by phenylmethylsulfonyl fluoride on delayed neurotoxicity induced by leptophos |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Delayed neurotoxicity |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Leptophos |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Phenylmethylsulfonyl fluoride (PMSF) |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Post-treatment |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Piao, Feng Yuan
Kitabatake, Masayoshi
Xie, Xiu Kui
Yamauchi, Toru
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Delayed neurotoxicity induced by leptophos, an organophosphorus insecticide, was intensified in hens when phenylmethylsulfonyl fluoride (PMSF) at dose of 30, 60, and 120 mg/kg body weight was administered at different time intervals (24 hr, 3 days, and 5 days) for each dose of PMSF after the hens were exposed to 30 mg/kg (i.v.) of leptophos. The scores for organophosphorus-induced delayed neuropathy (OPIDN) in all groups treated with 120 mg/kg PMSF were significantly higher than those in the group treated with leptophos only (P<0.05 or P<0.01) and the initial signs of OPIDN appeared 2 or 3 days earlier in the former groups than in the latter group. Further, the greater the PMSF post-treatment dose, the more severe were the signs of OPIDN. These findings indicate that post-treatment with PMSF promotes leptophosinduced OPIDN and reduces the period to OPIDN onset. We also examined the effects of various time intervals between PMSF administration and exposure to leptophos on the development of OPIDN. The OPIDN scores in the two groups of hen treated with PMSF on days 3 and 5 after leptophos exposure were high, especially the score of the 5 days treated group became significantly higher on the 18th and 19th day after leptophos administration than even that of the 24 hr treated group with PMSF (P<0.05). These findings suggest that variations in both the dose of PMSF and the time intervals of PMSF post-treatment may affect the delayed neurotoxicity induced by leptophos. Moreover, these results also indicate that PMSF should not be used for either the treatment or the prevention of OPIDN. |
| 書誌情報 |
Journal of toxicological sciences
巻 20,
号 5,
p. 609-617,
発行日 1995-11-25
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0388-1350 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00002808 |
| 権利 |
|
|
権利情報 |
日本トキシコロジー学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきCiNiiから複製したものである |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
日本トキシコロジー学会 |
| 関係URI |
|
|
|
関連名称 |
http://ci.nii.ac.jp/naid/110001805749/ |
| 資源タイプ（三重大） |
|
|
値 |
Journal Article / 学術雑誌論文 |
30A11330.pdf (644.2 kB)
