| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-04-01 |
| タイトル |
|
|
タイトル |
A case of usual (basaloid)-type vulvar intraepithelial neoplasia that failed to respond to imiquimod cream: clinical implications. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Vulvar intraepithelial neoplasia |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Imiquimod |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Human papilloma virus |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Shiozaki, Takaya
Tabata, Tsutomu
Toriyabe, Kuniaki
Motohashi, Takashi
Kondo, Eiji
Tanida, Kouji
Okugawa, Toshiharu
Sagawa, Norimasa
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The authors report a case of usual-type (basaloid-type) vulvar intraepithelial neoplasia (VIN) 3 that failed to respond to imiquimod cream. A 51-year-old Japanese woman visited her local gynecologist complaining of vulvar itching. Atypical cells were noted in cytology smears, but nine vulvar biopsy specimens showed benign proliferation of epithelial tissue. The patient was placed under careful observation for 8 months, when the vulvar smears once again showed atypical cells and biopsy specimens revealed VIN3. The patient was then referred to our hospital where she was given a diagnosis of VIN 3, basaloid type of usual type. The biopsy specimens were positive for p16 and the lesions were confirmed to be human papilloma virus (HPV)-related. We recommended simple vulvectomy but the patient requested conservative treatment with imiquimod cream. With her written informed consent, we prescribed imiquimod cream to be self-administered 3 times a week. Colposcopy and pap smear test were performed every 2 weeks. Four weeks after the start of treatment, a fingertip-sized papule was detected at the patient’s vaginal introitus. By 6 weeks, the lesion had enlarged, and biopsy specimens revealed invasive squamous cell carcinoma. At 7 weeks, we performed simple vulvectomy. The surgical specimen showed stage pT1b keratinizing-type squamous cell carcinoma. HPV-16 DNA was detected in the specimen. |
| 書誌情報 |
International Journal of Clinical Oncology
巻 16,
号 5,
p. 610-612,
発行日 2011-10-01
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1437-7772 |
| 権利 |
|
|
権利情報 |
(C) Japan Society of Clinical Oncology 2011 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 |
|
|
出版者 |
Springer Japan |
| 関係URI |
|
|
|
関連名称 |
http://link.springer.com/article/10.1007/s10147-010-0180-4# |
| ノート |
|
|
値 |
The original publication is available at www.springerlink.com |
| 資源タイプ（三重大） |
|
|
値 |
Journal Article / 学術雑誌論文 |
30A15283.pdf (1.7 MB)
