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Possible selection of viable human blastocysts after vitrification by monitoring morphological changes
http://hdl.handle.net/10076/14726
http://hdl.handle.net/10076/147267b80afc1-9fa0-430c-ab9e-a2f37af0ac84
名前 / ファイル | ライセンス | アクション |
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2014DM020.pdf (580.4 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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公開日 | 2015-10-22 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Possible selection of viable human blastocysts after vitrification by monitoring morphological changes | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | Vitrified-warmed blastocyst | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | Oxygen consumption | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | Time-lapse images | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | Embryo selection | |||||||||||
キーワード | ||||||||||||
主題Scheme | Other | |||||||||||
主題 | Embryo transfer | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
資源タイプ | doctoral thesis | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
著者 |
前沢, 忠志
× 前沢, 忠志
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Morphological assessment of human blastocysts has been effective for selecting embryos with high potential. However, they often show repeated shrinkage and expansion toward their hatching. Here we assessed whether capturing morphological changes over time of vitrified-warmed blastocysts could lead to a better selection of viable embryos from shrunken blastocysts. The implantation rates of vitrified-warmed blastocysts that were shrunken or expanded (developing) at the time of loading for transfer were compared among 2,729 cycles that were subjected to single blastocyst transfer. Vitrified (107) and fresh blastocysts (17) were donated for the experimental study. To assess the relationship between morphology (expanded vs. shrunken) and the mitochondrial respiration of blastocysts, the oxygen consumption rate (OCR) was analyzed for 55 specimens using an uncoupler of oxidative phosphorylation. The remaining 69 blastocysts were used for recording morphological changes every 15 min for 48 h after warming. Because there were no surplus embryos, 7 % of the vitrified-warmed blastocysts were shrunken and transferred. The shrunken embryos had sufficient implantation ability (40 %). The OCR of the shrunken embryos was significantly lower than that of their expanded counterparts. Upon exposure to the uncoupler, the OCR of some shrunken embryos increased to levels similar to the expanded specimens. Time-lapse images revealed some shrunken embryos which formed blastocoel by 5 h following warming exhibited developmental competence to the hatched stage. Data of the present study suggest a group of shrunken blastocysts contains many viable and clinically available embryos and time-lapse observation of vitrified-warmed blastocysts is a potential method to distinguish viable embryos from shrunken blastocysts. |
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内容記述 | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | 本文 / Mie Univ. ; IVF Namba Clin, Osaka ; IVF Osaka Clinic, Higashi-Osaka | |||||||||||
内容記述 | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | 8p | |||||||||||
書誌情報 |
発行日 2015-01-01 |
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DOI | ||||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.1007/s10815-014-0260-x | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | application/pdf | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
出版者 | ||||||||||||
出版者 | 三重大学 | |||||||||||
出版者(ヨミ) | ||||||||||||
ミエダイガク | ||||||||||||
関係URI | ||||||||||||
関連名称 | http://link.springer.com/article/10.1007%2Fs10815-014-0260-x | |||||||||||
学位名 | ||||||||||||
学位名 | 博士(医学) | |||||||||||
学位授与機関 | ||||||||||||
学位授与機関識別子Scheme | kakenhi | |||||||||||
学位授与機関識別子 | 14101 | |||||||||||
学位授与機関名 | 三重大学 | |||||||||||
学位授与年月日 | ||||||||||||
学位授与年月日 | 2015-03-25 | |||||||||||
学位授与番号 | ||||||||||||
学位授与番号 | 甲医学第1705号 | |||||||||||
ノート | ||||||||||||
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 31 (8), 2014, pp. 1099-1104, ISSN : 1058-0468に掲載 | ||||||||||||
資源タイプ(三重大) | ||||||||||||
Doctoral Dissertation / 博士論文 |