{"_buckets": {"deposit": "d9821e6c-5a15-4f33-8999-d5f26e873e9e"}, "_deposit": {"created_by": 15, "id": "8042", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "8042"}, "status": "published"}, "_oai": {"id": "oai:mie-u.repo.nii.ac.jp:00008042", "sets": ["1692670337748"]}, "author_link": ["19647", "19648", "19649", "19644", "19645", "19646"], "item_8_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-05-01", "bibliographicIssueDateType": "Issued"}}]}, "item_8_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "SUGIMURA, YOSHIKI", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "19647", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HASEGAWA, YOSHIHIRO", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "19648", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ISHII, KENICHIRO", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "19649", "nameIdentifierScheme": "WEKO"}]}]}, "item_8_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_8_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "組織発生時における形態形成は細胞同士であったり、細胞と細胞外マトリックス (ECM)との相互作用によって制御されている。テネイシンC (TN-C)は主に間質細胞が産生するECM分子の１つであり、本研究課題ではTN-C欠損マウス泌尿生殖洞間充織細胞 (TN-C KOマウスUGM)における遺伝子発現プロファイルを検討した。その結果、TN-C KOマウスUGMではthymosinβ10の他、chemotaxis, cell-matrix adhesion, response to wounding, collagen fibril organizationに属する遺伝子の発現が減少もくしは消失していることを見出し、間質由来TN-CシグナルもしくはTN-C関連シグナルが前立腺の発生や形態形成において重要な役割を担っている可能性を示した。", "subitem_description_type": "Abstract"}, {"subitem_description": "Morphogenesis in tissue development depends on the relationships among cells, the extracellular matrix (ECM), and other support structures. Tenascin-C (TN-C) is a hexametric glycoprotein of the ECM produced mainly by stromal cells. In this study, we evaluated the gene expression profiles in TN-C knockout (TN-C KO) mouse urogenital sinus mesenchyme (mUGM). In TN-C KO mUGM, the expressions of thymosinβ10 and specific genes related to chemotaxis, cell-matrix adhesion, response to wounding, and collagen fibril organization were decreased or disappeared as compared to those in WT mUGM, suggesting that stromal TN-C signals and/or related signals might play an important role in development and organogenesis of prostate.", "subitem_description_type": "Abstract"}]}, "item_8_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "2010年度～2012年度科学研究費補助金(基盤研究(C))研究成果報告書", "subitem_description_type": "Other"}]}, "item_8_description_64": {"attribute_name": "科研費番号", "attribute_value_mlt": [{"subitem_description": "22591764", "subitem_description_type": "Other"}]}, "item_8_publisher_30": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "三重大学"}]}, "item_8_text_18": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_text_value": "Role of extracellular environment on development and organogenesis in prostate and bladder"}]}, "item_8_text_65": {"attribute_name": "資源タイプ（三重大）", "attribute_value_mlt": [{"subitem_text_value": "Kaken / 科研費報告書"}]}, "item_8_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "杉村, 芳樹", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "19644", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "長谷川, 嘉弘", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "19645", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "石井, 健一朗", "creatorNameLang": "ja"}], "nameIdentifiers": [{"nameIdentifier": "19646", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-02-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "30K17174.pdf", "filesize": [{"value": "429.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 429600.0, "url": {"label": "30K17174.pdf", "url": "https://mie-u.repo.nii.ac.jp/record/8042/files/30K17174.pdf"}, "version_id": "9e8db4dc-2687-4f35-948b-1eeacfeaddb1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "細胞外マトリックス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "前立腺", "subitem_subject_scheme": "Other"}, {"subitem_subject": "膀胱", "subitem_subject_scheme": "Other"}, {"subitem_subject": "テネイシンC", "subitem_subject_scheme": "Other"}, {"subitem_subject": "泌尿生殖洞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "二核細胞", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "細胞外環境による前立腺・膀胱の発生や形態形成の制御機構", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "細胞外環境による前立腺・膀胱の発生や形態形成の制御機構", "subitem_title_language": "ja"}]}, "item_type_id": "8", "owner": "15", "path": ["1692670337748"], "permalink_uri": "http://hdl.handle.net/10076/14277", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2014-12-18"}, "publish_date": "2014-12-18", "publish_status": "0", "recid": "8042", "relation": {}, "relation_version_is_last": true, "title": ["細胞外環境による前立腺・膀胱の発生や形態形成の制御機構"], "weko_shared_id": -1}