| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-03-27 |
| タイトル |
|
|
タイトル |
原発性肝がんに対するシスプラチン・リピオドール療法時の有害事象調査 |
|
言語 |
ja |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cisplatin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
lipiodol |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
hepatocellular carcinoma |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
adverse events |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
thrombocytopenia |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
宮澤, 憲治
世古口, 典子
岩本, 卓也
村木, 優一
田中, 秀明
岩佐, 元雄
山門, 享一郎
竹田, 寛
竹井, 謙之
奥田, 真弘
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Transcatheter arterial embolization (TAB) and transcatheter arterial infusion (TAI) using cisplatin suspended in Lipiodol® Ultra-Fluide (Cisplatin/Lipiodol) are considered to be useful tumor-targeting therapies for hepatocellular carcinoma. However, little information is available on adverse events due to injection of Cisplatin/Lipiodol because the combined use Lipiodol and Cisplatin has not been approved by the Japanese government yet. Upon investigating the frequency and time of onset of adverse events following injection of Cisplatin/Lipiodol in 16 in-patients at Mie University Hospital, the frequency of the subjective symptoms of stomachache including epigastrium ache (75.0%), nausea or vomiting (50.0%), fever (50.0%), and gastric region discomfort (37.5%) was observed to be high. Further, leucocytes and neutrophils increased 2 days after injection (p< 0.001) and the onset of thrombocytopenia was much earlier than that following injection of Cisplatin alone. Severe adverse events defined as grade 3 or 4 in the Common Toxicity Criteria for Adverse Events Version 3.0 (JCOG/JSCO version, National Cancer Institute) were observed in 12 patients. These results suggest that great caution should be exercised with respect to adverse events occurring during Cisplatin/Lipiodol therapy. |
| 書誌情報 |
医療薬学
巻 34,
号 8,
p. 794-799,
発行日 2008-08-10
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1346-342X |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11527197 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| その他のタイトル |
|
|
値 |
Adverse Events due to Cisplatin-Lipiodol® Ultra-Fluide Suspension in Patients with Primary Hepatocellular Carcinoma |
| 出版者 |
|
|
出版者 |
日本医療薬学会 |
| 資源タイプ（三重大） |
|
|
値 |
Journal Article / 学術雑誌論文 |
39A16148.pdf (88.2 kB)
