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Localization and function of histamine H₃ receptor in the nasal mucosa
http://hdl.handle.net/10076/10175
http://hdl.handle.net/10076/1017589cf906d-e1a3-4d2c-84be-9ad1ddb26f09
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
takeuchi_3.pdf (12.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2009-04-21 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Localization and function of histamine H₃ receptor in the nasal mucosa | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | histamine H₃ receptor | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | (R)-α-methylhistamine | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | thioperamide | |||||||||||
| キーワード | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | submucosal gland | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
Suzuki, Shinya
× Suzuki, Shinya
× Takeuchi, Kazuhiko
× Majima, Yuichi
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | BACKGROUND: Histamine is an important chemical mediator of allergic rhinitis (AR). Histamine H₃ receptors H₃ are located on cholinergic and NANC neurons of the myenteric plexus, and activation of H₃R regulates gastric acid secretion. However, little is known about the localization and function of H₃R in the upper airway. OBJECTIVE: The objective of this study was to examine the localization and possible function of H₃R in the nasal mucosa. METHODS: We extracted total RNA from the inferior turbinate mucosa of patients with allergic rhinitis. Histamine H₃ receptor mRNA and β-actin mRNA were amplified by RT-PCR. We used immunohistochemistry to examine localization of H₃ receptor protein in the inferior turbinate mucosa excised during clinically indicated surgery. We used alcian blue/periodic acid-shiff(AB/PAS) staining to examine the effects of the histamine H₃ receptor agonist (R)-α-methylhistamine and the histamine H₃ receptor antagonist thioperamide on secretion from rat submucosal glands. RESULTS: Histamine H₃ receptor protein was expressed around submucosal gland cells. Thioperamide induced degranulation in the submucosal gland in the nasal septum. CONCLUSION: The present results suggest that histamine H₃ receptor is localized mainly around submucosal glands, and that histamine H₃ receptor plays an important part in secretion of submucosal glands in the nose. |
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| 内容記述 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | 上気道のリモデリングの特異性とその制御 | |||||||||||
| 書誌情報 |
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 巻 38, 号 9, p. 1476-1482, 発行日 2008-09-01 |
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| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 1365-2222 | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA10692471 | |||||||||||
| PubMed番号 | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 18564330 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1111/j.1365-2222.2008.03041.x | |||||||||||
| フォーマット | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | application/pdf | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
| 日本十進分類法 | ||||||||||||
| 主題Scheme | NDC | |||||||||||
| 主題 | 490 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Blackwell Scientific Publications | |||||||||||
| 著作の一部 | ||||||||||||
| 値 | http://hdl.handle.net/10076/10174 | |||||||||||
| 資源タイプ（三重大） | ||||||||||||
| 値 | Journal Article / 学術雑誌論文 | |||||||||||
