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Localization and function of histamine H₃ receptor in the nasal mucosa
http://hdl.handle.net/10076/10175
http://hdl.handle.net/10076/1017589cf906d-e1a3-4d2c-84be-9ad1ddb26f09
名前 / ファイル | ライセンス | アクション |
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takeuchi_3.pdf (12.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-04-21 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Localization and function of histamine H₃ receptor in the nasal mucosa | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | histamine H₃ receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | (R)-α-methylhistamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thioperamide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | submucosal gland | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Suzuki, Shinya
× Suzuki, Shinya× Takeuchi, Kazuhiko× Majima, Yuichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | BACKGROUND: Histamine is an important chemical mediator of allergic rhinitis (AR). Histamine H₃ receptors H₃ are located on cholinergic and NANC neurons of the myenteric plexus, and activation of H₃R regulates gastric acid secretion. However, little is known about the localization and function of H₃R in the upper airway. OBJECTIVE: The objective of this study was to examine the localization and possible function of H₃R in the nasal mucosa. METHODS: We extracted total RNA from the inferior turbinate mucosa of patients with allergic rhinitis. Histamine H₃ receptor mRNA and β-actin mRNA were amplified by RT-PCR. We used immunohistochemistry to examine localization of H₃ receptor protein in the inferior turbinate mucosa excised during clinically indicated surgery. We used alcian blue/periodic acid-shiff(AB/PAS) staining to examine the effects of the histamine H₃ receptor agonist (R)-α-methylhistamine and the histamine H₃ receptor antagonist thioperamide on secretion from rat submucosal glands. RESULTS: Histamine H₃ receptor protein was expressed around submucosal gland cells. Thioperamide induced degranulation in the submucosal gland in the nasal septum. CONCLUSION: The present results suggest that histamine H₃ receptor is localized mainly around submucosal glands, and that histamine H₃ receptor plays an important part in secretion of submucosal glands in the nose. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 上気道のリモデリングの特異性とその制御 | |||||
書誌情報 |
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 巻 38, 号 9, p. 1476-1482, 発行日 2008-09-01 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1365-2222 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10692471 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18564330 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/j.1365-2222.2008.03041.x | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
出版者 | ||||||
出版者 | Blackwell Scientific Publications | |||||
著作の一部 | ||||||
http://hdl.handle.net/10076/10174 | ||||||
資源タイプ(三重大) | ||||||
Journal Article / 学術雑誌論文 |