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炎症性サイトカインとmicroRNAは軟部腫瘍の診断・予後因子となりうるか?
http://hdl.handle.net/10076/00018068
http://hdl.handle.net/10076/00018068dc063125-03d5-4dd8-be71-a57a1969a83b
名前 / ファイル | ライセンス | アクション |
---|---|---|
2018RP0054 (163.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||||||
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公開日 | 2019-05-08 | |||||||||
タイトル | ||||||||||
言語 | ja | |||||||||
タイトル | 炎症性サイトカインとmicroRNAは軟部腫瘍の診断・予後因子となりうるか? | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Diagnostic and prognostic analysis for soft tissue tumor using inflammatory cytokine and micro RNA | |||||||||
言語 | ||||||||||
言語 | jpn | |||||||||
キーワード | ||||||||||
主題Scheme | Other | |||||||||
主題 | サイトカイン | |||||||||
資源タイプ | ||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||||||
資源タイプ | research report | |||||||||
著者 |
中村, 知樹
× 中村, 知樹
|
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | 軟部腫瘍において予後や診断に関連を示したものは血清IL-6であった.IL-17は,良性および悪性で感度よりも上昇している検体はなかった.またヘプシジンなども正常であった.IL-6は悪性軟部腫瘍で有意に上昇しており、Logistic 回帰分析ではIL-6値の上昇は悪性であるOdd比が1.17(p=0.004)であり悪性の診断に有意なマーカーであった.また悪性軟部腫瘍患者59例における血清IL-6は単変量でHazard Risk(95%信頼区間)1.005 (1.002-1.008),多変量解析でもHR(95%CI)1.003 (1.000-1.006)で有意に生命予後に関連していた. | |||||||||
抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | We measured several kind of cytokines. Interleukin(IL)-6 was related to diagnosis in 99 patients with soft tissue mass. But, other cytokines including IL-17 were not elevated using ELISA technique. C-reactive protein (CRP) was strong co-relation with IL-6. IL-6 was useful in differentiation between benign and malignant tumors. Furthermore, we analyzed prognostic variables including IL-6 in 59 patients with soft-tissue sarcoma. IL-6 was prognostic factor for survival and event-free survival in multivariate analysis. We conclude that IL-6 may be a useful marker for diagnosis of soft tissue mass and prognostic factors for survival in soft-tissue sarcoma. Now, we analyze the relationship between micro RNA and soft tissue sarcoma. | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 2015年度~2016年度科学研究費補助金(若手研究(B))研究成果報告書 | |||||||||
書誌情報 |
発行日 2017-05-22 |
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フォーマット | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | application/pdf | |||||||||
著者版フラグ | ||||||||||
出版タイプ | VoR | |||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
出版者 | ||||||||||
出版者 | 三重大学 | |||||||||
出版者(ヨミ) | ||||||||||
ミエダイガク | ||||||||||
科研費番号 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 15K18429 | |||||||||
資源タイプ(三重大) | ||||||||||
Kaken / 科研費報告書 |