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In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccins
http://hdl.handle.net/10076/9265
http://hdl.handle.net/10076/926533420143-d84f-4d12-8301-1d4b378e509d
名前 / ファイル | ライセンス | アクション |
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30A7841.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-10-24 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccins | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishikawa, Hiroyoshi
× Nishikawa, Hiroyoshi× Sato, Eiichi× Brions, Gabriel× Chen, Li-Mei× Matsuo, Mitsuyoshi× Nagata, Yasuhiro× Ritter, Gerd× Jäger, Elke× Nomura, Hideki× Kondo, Shigeto× Tawara, Isao× Kato, Takuma× Shiku, Hiroshi× Old, Lloyd J.× Galán, Jorge E.× Gnjatic, Sacha |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Bacterial vectors may offer many advantages over other antigen delivery systems for cancer vaccines. We engineered a Salmonella typhimurium vaccine strain to deliver the NY-ESO-1 tumor antigen (S. typhimurium-NY-ESO-1) through a type III protein secretion system. The S. typhimurium-NY-ESO-1 construct elicited NY-ESO-1-specific CD8+ and CD4+ T cells from peripheral blood lymphocytes of cancer patients in vitro. Oral administration of S. typhimurium-NY-ESO-1 to mice resulted in the regression of established NY-ESO-1-expressing tumors. Intratu-moral inoculation of S. typhimurium-NY-ESO-1 to NY-ESO-1-negative tumors resulted in delivery of antigen in vivo and led to tumor regression in the presence of preexisting NY-ESO-1-spedific CD8+ T cells. Specific T cell responses against at least 2 unrelated tumor antigens not contained in the vaccine were observed, demonstrating epitope spreading. We propose that antigen delivery through the S. typhimurium type III secretion system is a promising novel strategy for cancer vaccine development. | |||||
書誌情報 |
The journal of clinical investigation 巻 116, 号 7, p. 1946-1954, 発行日 2006-07-03 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0021-9738 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695520 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1172/JCI28045 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
出版者 | ||||||
出版者 | American Society for Clinical Investigation | |||||
関係URI | ||||||
関連名称 | http://www.jci.org/articles/view/JCI28045 | |||||
関係URI | ||||||
関連名称 | http://www.pubmedcentral.nih.gov/articlerender.fcgi?pubmedid=16794737 | |||||
ノート | ||||||
出版者版電子ジャーナルあり | ||||||
資源タイプ(三重大) | ||||||
Journal Article / 学術雑誌論文 |